Online Pharmacy - Up to 80% Off Generic Drugs
Compare Prices and Check Full List of Drugs

Posts Tagged ‘blood tests’

Testings During Pregnancy. FAQ

Monday, June 1st, 2009

Testings During Pregnancy. FAQ

Testing, testing
investigations in pregnancy
What is the difference between diagnostic and screening tests?
Screening tests identify your baby’s ”risk factor” for a particular condition, but do not confirm that your baby definitely has a condition. For example, a screening test for Down’s syndrome may give your baby a risk factor of 1:200 This means that your baby has a 1 in 200 chance of being affected by Down’s syndrome. Another way to view this result could be that the baby is most likely to be healthy. If your baby has a high risk factor, you may then decide to have a diagnostic test, such as amniocentesis or chorionic villus sampling (see pp 122-123), which gives a definite yes or no as to whether or not a condition is present. These tests are more invasive, as they require a sample of amniotic fluid or blood from the fetus or placenta, and they carry a slight risk of miscarriage.
Certain screening tests, such as first- or second-trimester screening for Down’s syndrome, are offered routinely to all women regardless of any factor other than they are pregnant. These tests, in the form of scans or blood tests, identify who would benefit from further diagnostic tests. This avoids subjecting all pregnant women to diagnostic tests, which carry some risks (see p. 125). Any benefit from a test should outweigh the potential risk.
What do these tests look for?
Screening and diagnostic tests aim to identify abnormalities in the unborn baby, which may be congenital, genetic, or chromosomal. Congenital abnormalities are often detected in the 18-22 week scan (see p.121) and these include conditions such as heart abnormalities or extra digits These abnormalities can sometimes be treated after, or sometimes even before, the birth and are not inherited. Some conditions, such as spina bifida, are thought to be due to a combination of genetic and
environmental factors; a dietary deficiency of folic acid may also contribute to this condition. Other congenital abnormalities may be caused by infections caught in pregnancy.
Diagnostic tests are usually carried out to identify genetic or chromosomal abnormalities, such as Down’s syndrome, cystic fibrosis, sickle-cell anaemia, and muscular dystrophy. (Cystic fibrosis and muscular dystrophy are screened for if there is a family history) These conditions occur either because there is a problem with the inherited genetic material, for example a gene has mutated, or because there is a chromosomal problem, for example there may be an incorrect number of chromosomes, as in Down’s.
Down’s syndrome, or ”trisomy 21”, is a chromosomal abnormality in which there is an extra copy of the chromosome 21. It is the most common ”trisomy” disorder. Babies born with this condition have physical anomalies, such as slanting eyes and
a protruding tongue, and there is a high incidence of heart, intestinal, hearing, and sight problems. Down’s is the biggest single cause of learning difficulties. The majority of Down’s syndrome conceptions are lost through spontaneous miscarriage early on in pregnancy, although over 600 babies are born with Down’s syndrome in the UK each year.
I’m 38 - will I have more tests because I’m older?
Although the risk of Down’s syndrome increases as you get older (see p 118) currently many women regardless of age are offered one of two types of screening test for Down’s. This is either a first trimester screening that involves a blood test and a scan to measure nuchal translucency (see p.118), or second trimester screening which is a blood test only, called the triple, or Bart’s. test (see below) Both tests give the result as a risk or a percentage risk. If the test indicates there is a high risk of Down’s, then all women are offered a diagnostic test such as amniocentesis (see p.123). However, if you are over 35. amniocentesis is offered routinely in the UK.
Your midwife should discuss with you in detail all the tests that are available and give you written information about them. Ideally, you should have this information several weeks before you are asked to decide if you wish to go ahead with any screening or diagnostic tests so that you have plenty of time to consider the possible outcomes and whether these tests are something -you wish to undergo
Depending on your past medical history and other factors, such as your blood pressure during your pregnancy or problems you had in previous pregnancies, you may be offered additional scans to check your baby’s growth after 26-28 weeks.
We don’t want invasive tests as we will love the baby whatever. Can we refuse diagnostic tests?
Whether or not you have a diagnostic test is your choice and you can refuse at any time to have any test offered As well as the question of whether you are prepared to have a Down’s baby, there is also the risk of miscarriage to consider (see p.125) On the other hand, you might decide you want a definite diagnosis to be able to prepare for your child.
What blood tests will I be having, and when?
There are various blood tests offered during pregnancy As well as routine blood tests taken during antenatal checks to assess your health, there are also blood tests to screen for problems with the baby. Within the first 12 weeks you will be given a routine blood test to check your levels of haemoglobin, the oxygen-carrying part of blood. Although these fall slightly in pregnancy as the blood becomes more diluted, a significantly low haemoglobin level indicates iron-deficiency anaemia (see p 8 1). You will also have tests to identify your blood group, Rhesus factor, and rubella immunity (see p 15). and to screen for infectious diseases including syphilis, HIV, and hepatitis B. You may also be tested for sickle cell and thalassaemia, inherited blood conditions more commonly found in people of African, Caribbean, Indian, or southern Mediterranean origin.
Other blood tests may be offered to screen for congenital abnormalities in the baby Between 10 and 14 weeks, a blood test that measures the levels of the substance known as pregnancy associated plasma protein (PAPP-A) may be offered that is combined with the nuchal translucency scan (see opposite) to calculate a risk of Down’s syndrome.
If first trimester Down’s syndrome screening isn’t available, then second trimester blood screening tests are offered, which also include screening for neural tube defects, such as spina bifida These tests, carried out between 16 and 18 weeks, include the triple, or Bart’s, test, which measures the levels of the hormones AFR hCG, and oestriol; and the quadruple test, which, in addition to the other three hormones, measures inhibin A and PAPP-A.
Will I have a test for HIV?
Ali screening and diagnostic tests recommended in pregnancy are optional, so it is up to you and your partner to decide whether to have them. One of these is a blood test to check if you have the human immuno-deficiency virus, or HIV, and, indeed, some women only find out about their HIV status in pregnancy It is worthwhile to test for HIV in pregnancy as, if the result is positive, anti-retroviral medication, careful monitoring of maternal blood levels, and careful, safe delivery of the baby can reduce the chance of transferring the infection to the baby from 40 per cent to 2 per cent.
For pregnant women with HrV, a blood test is taken around the time of delivery to measure the levels of the virus. Depending on the results of the blood test, the obstetrician will either recommend a planned Caesarean section or decide that the levels are low enough to have a normal delivery.
After the delivery, HIV-positive mothers are advised to bottlefeed, again to reduce the risk of transferring the virus to the baby
How do ultrasound scans work?
Ultrasound scans use high-frequency sound waves — so high we can’t hear them — that bounce off solid objects and create a picture, visible on a
computer screen, of your baby, the placenta, and your organs in the surrounding area.
How many scans will I have and when?
All women should routinely be offered two scans, a dating scan between 10 and 14 weeks and an anomaly scan between 18 and 22 weeks. Some units routinely offer a screening scan for Down’s syndrome between 11 and 14 weeks, known as the nuchal scan (see opposite), although this isn’t available nationwide. You can also arrange to have private scans that may be 3D/4D (see p, 124) and which you have to pay for
I’m quite scared about my first scan. What happens during the scan and what does it feel like?
Although not painful, early scans can cause discomfort as you need a full bladder (see p, 124). Ultrasound scans can be carried out by a doctor,
a midwife, or a sonographer. You will lie on a couch and need to wear something that makes it easy to expose your tummy. The person doing the scan puts cold gel on the lower part of your tummy, which improves contact with the skin, making it easier to view the baby. You will feel a little pressure as a transducer is pressed against your skin and moved around to look at the baby from different angles and to take measurements The image produced by the scan is viewed on a screen similar to a computer monitor. The person carrying out the scan may spend some time first studying the image and taking measurements before talking to you about what they can see Although this can be unnerving, it does not mean that anything is wrong
Some units offer a transvaginal scan in early pregnancy, which can give an improved image at this stage. This internal scan is done using a probe that is covered by a condom and gently inserted into your vagina. The image is viewed on the screen in the same way as an abdominal scan. This may be offered before 10 weeks if there is bleeding or pain.
Many units offer to print an image from the scan for you to take home Although ultrasound scans
Should I have a scan? is ultrasound safe ill pregnancy’?
Ultrasound scans in pregnancy, first introduced 40 years ago, have become a routine part of antenatal care.
* Most research indicates that they are a safe way to view the baby even when extra scans are needed for medical reasons * Suggested links between additional scans and growth problems and dyslexia are tentative as babies scanned more often are more likely to have problems linked to other factors.
* Recommendations are that scans are carried out only for clinical reasons and the number done is kept to a minimum.
How long do scans last?
The length of time an ultrasound scan takes varies depending on the reason for the scan and the experience of the ultrasonographer.
During the dating scan, performed at around 10-14 weeks, the sonographer takes some basic measurements. This includes the measurement from the top of the head to the end of the bottom, known as the ”crown-rump” measurement, used to calculate how many weeks old your baby is and
therefore your due date. This scan can take around 20-30 minutes. The nuchal fold scan (see p 118), during which the sonographer measures the fluid at the back of the baby’s neck, takes around 20 minutes. Anomaly scans, performed between 18 and 22 weeks, are detailed scans that take approximately 40 minutes (see opposite) At this scan, the sonographer measures the baby and looks at physical and structural development. The size and position of the placenta are examined and the amniotic fluid around the baby is measured
If, during your pregnancy, your midwife has any concerns about your baby’s growth or wellbeing, she may refer you to an obstetrician who may recommend another scan. As this will be to identify a specific problem, such as whether there is a concern about your baby’s growth, it may take a bit longer. This may be in the form of a Doppler scan, which measures the blood flow in the uterus, placenta, and umbilical cord and can help to identify growth problems in the baby This procedure usually takes around 30 minutes.
Do I have to have scans in pregnancy?
Official guidelines are that all women should be offered two routine scans during their pregnancy, but the choice to have one is yours. As scans are screening tests to look for anything out of the ordinary some women choose not to have any as they prefer not to know about any problems until the baby is born, or are confident that they will continue with the pregnancy regardless. You need to decide whether you fall into this category
Can my partner come along for the scans?
There is no reason why your partner should be excluded from attending these appointments if you want him to be there and, indeed, it’s very common for partners to attend ultrasound scans For many couples, the scan is a special moment as it’s the first time they get to see their baby and begin to think of themselves as parents.
primarily area clinical screening tool to determine if your baby is growing and developing as expected, they are also an opportunity to see your baby for the first time and often see your baby moving even before you feel the first flutters inside your uterus.
So scans become part of the developing relationship between you and your partner and the baby. In recognition of this, most units offer the facility of providing photos of the scan for a small charge to cover printing costs. Ask your community midwife whether the maternity unit where you are having your scan has this facility.
Do you have to drink pints of water before a scan? I’m scared I’ll have an accident.
For the 10-14 week dating scan it’s important to have a full bladder to make it possible to view the baby. This is because until 12 weeks the uterus stays in the pelvis and the bowel obscures the view. a full bladder raises the uterus and pushes the bowel out of the way. You may need a full bladder for a nuchal scan, between 11 and 14 weeks, depending on when it is done. Some units do transvaginal. scans (a small ultrasound probe placed inside your vagina) before 10 weeks if the image from an abdominal scan is poor In this case, you won’t need a full bladder and research indicates that transvaginal scans are more comfortable in early pregnancy compared to abdominal scans. You don’t need a full bladder for the 18-20-week scan, as the position of the uterus has changed
I’m pregnant through IVE Will I have more scans than normal?
It’s usual to have one extra scan in an IVF pregnancy usually carried out by the centre where you had the
3D and 4D ultrasounds
Many companies now offer special scans that reveal your baby in three dimensions or moving on film or video. These 26-32 week scans can be quite expensive and are carried out for curiosity value and not for medical reasons The quality of the pictures is usually amazing and parents are sometimes able to spot genetic similarities between themselves and
procedure This scan is usually done around two weeks after the embryo has been transferred to confirm the pregnancy and make sure that the pregnancy is within the uterus rather than in a Fallopian tube (see ectopic pregnancy, p.25) Although the main purpose is to reassure you that all is well, the centre also has to inform the Human Fertilisation and Embryology Authority (HYEA) of the outcome of the IVF treatment. Once your pregnancy is confirmed, you will continue with routine antenatal care like any other pregnancy
Can they really tell the sex
of the baby early on? I’m 18
weeks and not sure if I want to know.
It is possible to identify the sex of a baby on routine ultrasound scans from around 20 weeks, but this is dependent on a number of factors, including the expertise of the person performing the ultrasound, the quality of the equipment being used, the position the baby is lying in, and the position of his or her legs. Even if all of these factors are favourable and the genitalia can be seen, there is an error factor, so
their baby However, the scan is often lengthy which means the baby is exposed to ultrasound for longer than is normal Also, if the baby is in the wrong position, it may be difficult to get a clear picture The position of the placenta, the amount of amniotic fluid, and the size of the mother can also affect the quality of the pictures obtained  the information given about gender from a scan is never seen as 100 per cent accurate Some research has been carried out to try and determine gender at an earlier stage, but this was even less accurate. Sometimes when you are watching the scan you may be able to see the genitalia yourself and may decide you know the sex of your baby without being told. But remember you may be wrong. If you have an amniocentesis the sex of the baby can be definitely identified during the procedure.
Most units have a written policy only to reveal the baby’s sex if this information is requested Some units have a policy of not telling anyone the sex of the baby from scans alone, partly because they cannot be 100 per cent accurate and also because, in a small number of cases, the information about gender may lead to a request for termination. If you want to know the policy in your area, ask your community midwife.
I’ve seen lots of companies advertising scans and videos of scans - are these safe?
Many companies offer 3D scans (still pictures) and 4D scans (moving pictures copied onto video or DVD) (see opposite), and the detail in these can be very good. If you have a private scan, you should check the expertise of the person carrying out the scan, and check if the company has a referral policy to an appropriate consultant obstetrician if anything untoward is discovered, as not all companies employ the services of obstetricians or midwives.
There are twins in our family. When will they be able to check whether I’m having twins?
Most women find out that they are having twins
at their ultrasound dating scan between 10 and 14 weeks Very occasionally, one twin is hidden on the first scan and is seen at the second ultrasound scan, but nowadays this is less likely due to advances in scanning Family history also gives a clue to the possibility of twins, but only if they are fraternal, or non-identical (see p.129).
Is everyone offered amniocentesis?
Amniocentesis is a diagnostic test (see p 123) that is routinely offered if you are over 35 and so have a higher risk of having a baby with Down’s syndrome Alternatively, you may be offered the test if your family history suggests there may be a risk of your baby having muscular dystrophy, haemophilia, cystic fibrosis, or another genetic disorder. Also, if you have had a screening test that suggests your baby has a high risk for a congenital condition, you will be offered a diagnostic test to confirm or rule it out For example, if the nuchal scan (see p.118) showed a high risk of Down’s, amniocentesis may be offered.
I’ve heard that amniocentesis carries a risk. Is this true?
Amniocentesis does carry a small risk of miscarriage. It is thought that the risk of miscarriage is increased above the normal risk by 1 per cent immediately following an amniocentesis, but after two days the risk returns to normal. You need to balance the risk against the value of the test to you and also be aware that a normal test result is not a guarantee that there will not be any other problems, but is nonetheless reassuring
Can chorionic villus sampling cause miscarriage?
Chorionic villus sampling (CVS) is another diagnostic test used to establish whether a baby has Down’s syndrome (see p.122). Unfortunately, as with other invasive tests, this carries a risk of miscarriage, of around 1.5-2 per cent, with the risk reducing each day, Larger hospitals carrying out more than 100 CVS tests a year may have lower miscarriage rates due to the opportunity for the doctors to fine tune their ability to carry out the procedure.
When is cordocentesis used?
Cordocentesis is a diagnostic test used to diagnose Down’s syndrome and other problems
in a baby It can also detect infection from diseases such as toxoplasmosis (see p.45). Additionally,
cordocentesis is used to detect rubella infection (see p.15), as well as to perform a blood count on a baby that is suspected of having anaemia From 18 weeks, the baby’s blood is examined using a sample of
blood carefully extracted from the umbilical cord The test is carried out in a similar way to that of amniocentesis, though results are available within 72 hours. The risk of miscarriage is 1-2 per cent.
Will I get weighed at my antenatal appointments?
In 1941, routine weighing of all pregnant women at each antenatal appointment began Although it was thought that there was a connection between a mother’s weight gain and a baby’s birth weight,
it was decided more recently that this is not a good indicator of when a baby is not growing, and so over the last 10 years routine weighing at each appointment has been abandoned. Furthermore, weight gain can vary from woman to woman in normal healthy pregnancies as widely as 3-18 kg (7-401b).
Nowadays, all women are weighed once at the beginning of pregnancy and then, together with a height measurement, their BMI (body mass index) is calculated (see p.18), which helps to predict certain risk factors, for example in women who have a very high or very low BMI The only time that you might be weighed on successive visits is if there is a medical reason to do so, for example if you had significant weight gain in a short space of time that could indicate excessive fluid retention (oedema), a sign of pre-eclampsia (see p 89).
My friend is 27 and has had a Down’s baby - is that unusual?
Although the risk or chance of having a baby with Down’s syndrome increases with age, particularly over 35, the majority of Down’s babies are born to younger mothers. This is probably due to the fact that more women have their babies younger, and also because women over 35 are likely to have more tests The risk of having a baby with Down’s at the age of 20 years is 1 in 1,700. This risk increases to 1 in 1,400 by the age of 25 and by the time the mother reaches 35, the risk has increased to about 1 in 400
My partner wants to hire a Doppler so we can listen to the baby’s heartbeat. Is this a good idea?
During pregnancy your midwife listens to the baby , s heartbeat with an instrument called a Doppler sonicaid or pinard (ear trumpet). Most midwives use a sonicaid so the parents can hear the heartbeat too This passes sound waves through the abdomen. which pick up movement and bounce it back to the machine, where it is converted into sound.
Being able to hear your baby’s heartbeat during pregnancy is reassuring, especially when the earlier symptoms wear off but the baby’s movements have yet to be felt. However, your baby’s heart beats at a rate approximately double the rate of your heart. If the closest moving thing to the ”beam” is your blood pulsating through your aorta, the sonicaid will pick this up, and if you pick up your heart rate, this might cause you anxiety Also, depending on your gestation and the position of your baby the heartbeat will be found in different areas on the abdomen. If you can’t pick up a heartbeat, you may be unduly worried.
Midwives undergo specialist training to find the heartbeat and many won’t try to find the heartbeat until the baby is around 16 weeks, and even then may have difficulty Occasionally, due to the baby’s position, they may need to call another midwife or doctor to help them locate the heartbeat
It is up to you and your partner if you decide to hire a sonicaid, but it would be wise to be aware of the anxieties that may accompany this decision.

 

 
The 18-22 week anomaly scan
Your baby’s physical examination
Also known as the fetal anomaly or anatomy scan, this detailed scan is offered to all women between the 18th and 22nd week of pregnancy. At this stage of gestation, your baby has well-developed limbs and facial features and all its major organs and
body systems are in place and can be checked.
How is it done? The scan involves transmitting high-frequency sound waves through the uterus that bounce off the baby and the returning sounds are converted into an image (see p.119), The biggest echoes are from hard tissues, such as bones, which appear white in the image on the screen, while soft tissues are grey-flecked. Fluid-filled spaces, such as the stomach, bladder, blood vessels, and amniotic fluid surrounding the baby, do not return sound waves so appear black. It is
the difference between echoes and colours that enables the ultrasonographer to interpret images
What will be checked? The ultrasonographer starts by checking the fetal heartbeat and then counts the babies - rarely, twins are not revealed until 20 weeks! She will measure the head circumference and diameter (biparietal diameter), and the abdominal circumference and the femur (thigh bone) to date the pregnancy and ensure your baby is growing well She will check for abnormalities in the brain, face and lips, spine, abdomen, heart, stomach, kidneys, bladder, and hands and feet. Lastly, the placenta, umbilical cord, and amniotic fluid are examined You may be able to find out the sex of your baby, although you can ask not to be given this information (see p.124).

 

Diagnostic tests
Identifying fetal abnormalities
Diagnostic tests give a definitive answer as to whether or not your baby has an abnormality such as Down’s syndrome These tests are not carried out routinely and you will be offered one only if a screening test indicated that your baby had a higher risk for Down’s syndrome, if you are over 35, or you have a family history that puts you at a higher risk of having a baby with an abnormality, All diagnostic tests also carry a small risk of miscarriage and you will need to weigh up the pros and cons before deciding to go ahead with one
Chorionic villus sampling (CVS) This is a
diagnostic test that involves taking a tissue sample from the placenta to identify for certain whether your baby has Down’s syndrome or a genetic
Chorionic villus sampling
needle and
syringe  ultrasound transducer
abnormality This can be done as the placenta contains the same genetic information as the baby The test is carried out between 11 and 13 weeks, The advantage of this test is that it can be performed earlier in pregnancy than amniocentesis, so if an abnormality is found and you decide to terminate, it is early enough to have a suction termination.
How is it done? There are two procedures for CVS: one method extracts a sample of the placenta via the abdomen, and the other method carries out the procedure vaginally With the abdominal method, a fine needle is inserted through your abdomen and, using an ultrasound scan for guidance, the doctor removes a very small sample of tissue from the placenta You have to wait about
ultrasound transducer
catheter 10 days for the results, which means that if your baby has an abnormality and you want to terminate your pregnancy, you can do so well before you start to feel your baby kicking.
To carry out CVS vaginally the doctor inserts a small tube through your vagina and the cervix, which then passes through the uterine wall. As with the abdominal method, the doctor then takes a small sample of tissue from the placenta, using ultrasound for guidance. The sample is sent to a laboratory where it is grown in a culture for around seven days. The sample is then studied under a microscope to check for chromosomal abnormalities or other defects.
Amniocentesis Amniocentesis is a diagnostic test used mainly to identify a chromosomal abnormality and it is the most commonly used test for identifying Down’s syndrome. During the test, a sample of amniotic fluid containing cells from the baby’s system is taken from the uterus. It is a relatively quick and painless
Amniocentesis test
ultrasound — needle and
transducer syringe
placenta uterus — amniotic  
fluid
cervix
procedure and may be offered at around 16-19 weeks of pregnancy It is offered later than CVS because there may be insufficient fetal cells in the amniotic fluid before this stage of pregnancy The results from this procedure are usually very accurate and, although there is a slight risk of miscarriage, this is lower than the risk of miscarriage with CVS, especially in units where a large number of the tests are carried out and the doctors are particularly practised at conducting the test Apart from the slight risk of miscarriage, the main disadvantage of amniocentesis is that it has to be carried out later in pregnancy, so if the result comes back as positive, then you will be half way or even further into your pregnancy should you decide to terminate and would need to be induced to undergo a vaginal delivery
How is it done? Using an ultrasound scan to guide the procedure, a long, thin needle is inserted through the mother’s abdomen into the amniotic sac and a small sample of amniotic fluid is extracted. This contains fetal cells, which are then grown in a culture in a laboratory to be analysed. As there is a small risk of miscarriage, you may be advised to rest for a day or two afterwards to minimize this risk. Depending on the maternity unit and the laboratories used, there may be a chance that the result could be back before the end of one week, but the majority of units still have to wait two or even three weeks. It usually takes 2-3 weeks for the fetal cells to grow, Very occasionally this does not happen and you may need to have another amniocentesis test
Cordocentesis This diagnostic test is also known as ”fetal blood sampling” or “umbilical vein sampling”. In this test, blood is taken from the baby’s umbilical cord to diagnose Down’s syndrome when earlier screening tests have shown a possible problem. Since this is an extremely specialized procedure, it can only be carried out at a regional specialist fetal medicine centre in certain parts of the country.

 
Nuchal fold and dating scans
Ultrasound examinations
A dating scan at 10-14 weeks measures fetal growth so that a gestational age can be given The nuchal fold scan, or nuchal translucency scan, is offered between weeks 11 and 14 and assesses the risk of Down’s syndrome. Only some hospitals offer this scan at the moment The risk of Down’s syndrome rises with age. At 20 the risk is 1:1527; at 25 it is 1:1352; at 30 it is 1:1895; at 35 it is 1: 356; and at 40 it is 1,97,
What does the dating scan look for? The distance is measured from the top of the baby’s head to its bottom (crown-rump measurement), and the diameter of the head is recorded, known as the biparietal diameter - the distance between the parietal bones either side of the head
How is the nuchal fold scan done? The sonographer will measure the width of the fold of
skin behind your baby’s neck to see if any excess fluid has collected there This measurement is calculated into a risk ratio based on your age The ratio is considered high if it is above 1:300. You will be given the results of the scan immediately If your baby has a high risk, you will be offered further tests and, depending on the results and after counselling, the choice of continuing your pregnancy with support or having a termination.
Is it reliable? The nuchal fold scan is considered to be 80 per cent accurate, which means there is a 20 per cent (1:5) chance of it being inaccurate If your hospital offers you a blood test (PAPP-A, see p.119) with the scan, it becomes 85 to 90 per cent accurate. When the nasal bone is also measured, the accuracy rises to 95 per cent. Your local maternity unit should be able to provide you with information as to how accurate their scans are.

Not Getting Pregnant FAQs. I am not getting pregnant.

Wednesday, May 27th, 2009

Not Getting Pregnant FAQs.

We’re not getting pregnant what do we do now?
We’ve been trying to conceive for 12 months - can the doctor identify the problem?
There are many factors that can increase or decrease your chances of becoming pregnant, but if you have been trying for a year, it would be sensible to contact your doctor. After an initial assessment of your general health and lifestyle, your doctor will offer your partner a sperm test (see below) and you will be offered tests to see if you are producing eggs and check whether or not your Fallopian tubes are blocked. Blood tests will be carried out to check your iron levels, your red and white blood cell count, and to check how organs such as your liver and kidneys are functioning In addition, couples are asked to agree to a sexual health screening to check for previous or current STls, such as HIV and syphilis.

My wife has been tested and has the all clear - how can I tell if I’m causing our fertility problem?
You will be offered a semen analysis to determine your sperm quantity and quality — how sperm move (motility) and whether they are a normal form. A healthy sperm count should have a concentration of 20 million spermatozoa per millilitre of semen, with
75 per cent of these alive and 50 per cent of these ‘motile”, or moving as well as possible Differences can occur over time in both the quality and quantity of sperm, so if your first sample is poor, you will probably be tested again a couple of months later.
You are also likely to be advised to give up smoking, reduce alcohol intake to 1-2 units once or twice a week, and to wear loose-fitting underwear to avoid overheating the testes If a problem is found, you will be referred to a specialist for a consultation Try to avoid becoming stressed as this can also affect fertility Learning relaxation techniques with your partner and practising these regularly will help.

We can’t conceive naturally - what do we do now?
Assisted conception; or assisted reproduction, is the term used when women are helped to conceive without having intercourse There are five main procedures available, listed below. Your consultant will go through each one with you, and together you can make a decision about which is most suitable depending on your problem. You can also contact the National Institute for Health and Clinical Excellence (NICE) for more information (see p.310)
* Ovarian Stimulation (OS), or Super Ovulation (SO), involves injections of fertility hormones to boost egg production This is followed by intrauterine insemination (IUI) of sperm, whereby sperm are collected and sorted so that only the strongest remain and these are then artifically placed inside the uterus via a catheter. This is ideal for couples when the man’s sperm is “slow” or the woman has problems ovulating, or there is a combination of both. * Gamete Intra-Fallopian Transfer (GIFT). This is suitable for couples for whom no cause for infertility has been found. It involves stimulating the ovaries to produce eggs, which are removed, mixed withsperm and replaced directly into the Fallopian tubes, allowing conception to occur inside the body.
* In Vitro Fertilization (IVF). This is the most widely used treatment and involves a seven-step process (see below and p.30) This is ideal for most problems including blocked tubes
* Intra-Cytoplasmic Sperm Injection (ICSI). This is used if the man’s sperm count is low, the motility of the sperm is very poor, or the woman is allergic to her partner’s sperm. The treatment involves injecting just one viable sperm into an egg (see box right). * Artificial Insemination by Donor (AID). This is simply the injection of donated sperm into the cervix This is used when a man is unable to maintain an erection or is sterile Similarly, women may require an egg donation if they are unable to produce their own eggs, although this is more complicated.
Whatever treatment is provided, it is important that you and your partner are treated as a couple rather than separate patients. It is also essential that you are kept informed throughout the process and given information on any risks and benefits.

What does IVF involve?
IVF, or In Vitro Fertilization, involves the surgical removal of an egg which is then mixed with sperm in a laboratory dish to fertilize and produce an embryo outside of the womb (see p.30).
IVF treatment occurs in cycles, as there are various stages that must be completed for it to be successful. Initially, a drug is used in the form of a nasal spray or injection to switch off the woman’s natural cycle of egg production in the ovaries, known as ”clown-regulation”. Fertility drugs are then given to stimulate the ovaries to produce more than one egg (ovulation induction). Mature eggs are collected from the ovaries using a fine needle guided by ultrasound. The procedure is usually uncomfortable rather than painful. On the same day, the partner’s sperm is collected and then the eggs and sperm are mixed in a dish. Within a few days, one or sometimes two embryos are transferred into the womb. If an embryo successfully attaches to the inside of the womb and continues to grow, a pregnancy results.

ICSI

This procedure may be used when it is thought that the quality of the partner’s sperm may be responsible for fertility problems. If the sperm count is low or movement is poor, sperm may be ”assisted” in fertilizing the egg. An individual sperm is injected directly into the egg and, if fertilization takes place, the resulting embryo is placed in the uterus.
What are the success rates of fertility treatments?
Success rates for treatments vary, depending on the treatments used and the health of the couple If you want to know the success rates of individual clinics, you can ask for their ratio of “live-births-per-cyclestarted”. This information is available from each clinic, but there are currently no nationally held data
Overall, couples have a better success rate if the woman is aged 23-39 years, has been pregnant or has had a baby, and has a normal body weight (a body mass index between 19 and 24). The older a woman is, the less likely she is to get pregnant
Figures show that for every 100 women who are 23 to 35 years, more than 20 will get pregnant after one PVT cycle; from 36 to 38 years around 15 will get pregnant at 39, around 10 will get pregnant; and in women over 40, around 6 will get pregnant

IVF is so expensive - can we get help with funding?
Since April 2005, women between the ages of 23 and 39 are entitled to one free IVF cycle on the NHS. However, you must meet the eligibility criteria set by your local Primary Care Trust (PCT), which varies across the country and depends on factors such as your marital status, weight, and whether you or your partner smoke Couples who can afford to, or who may have had one unsuccessful cycle already, often opt for a private clinic Although these are regulated by the Human Fertilisation and Embryology Authority (HFEA), this cannot set costs, and a private course of IVF can cost from E4,000 to £10,000
My partner is worried about producing his sperm sample. How can I reassure him?
As fertility problems affect 1 in 7 couples in the UK reassuring your partner that this is not an unusual situation is always a good start. You could try leaving out a leaflet on fertility problems for him to read for more information Try to empathize with him as much as possible by sharing your experiences and the tests you have undergone.
Your partner may be worried about ejaculating at the required time when he is already feeling anxious and is in a clinical environment Some men require a sex toy, magazines, or video clips to help. For others, restraining from sexual intercourse for a few days can make ejaculation easier If you live fairly close to the clinic, your partner may be able to produce the sample at home and deliver it.
Sometimes a medical condition such as diabetes prevents a man ejaculating If this is the case, sperm can be obtained through ‘’sperm recovery”, whereby a small needle is passed through the skin of the scrotum into the testes and sperm is withdrawn.

The drugs I’m taking for IVF are giving me terrible mood swings. Is this normal?
The drugs used in IVF treatment are female hormones (see p.30) to stimulate your ovaries to mature more than one egg at a time, and progesterone, which helps to sustain a pregnancy. Different levels of hormones can result in mood swings, as any woman who suffers with premenstrual tension (PMT) can testify, and this is also a common side effect of IVF treatment It’s worth considering too that couples undergoing IVF are under incredible stress, which has been linked to an increased risk of developing depression, so it’s important to decide whether you are feeling ”hormonal” or are in fact depressed. Your doctor can advise you and refer you if necessary.
My partner has a low sperm count - can you tell us what help is available for us?
Usually, two or three semen samples are taken to work out the average sperm count and to see if there are abnormal sperm present. A healthy semen sample of 2-5ml contains more than 20 million sperm per ml; a count below this is considered low If your partner has abnormal sperm, further testing may be necessary Lifestyle changes can boost sperm (see below). There are also hormonal treatments to improve sperm count and surgery to remove blockages You may be reassured to know that even poor-quality semen can be used to fertilize an egg with IVF or with ICSI (see p.29).
Can lifestyle changes really improve sperm?
Poor quality sperm has been linked to excessive drinking (more than three or four units of alcohol per day), smoking, and to wearing tight-fitting underwear,
which overheats the testicles and can affect their efficiency Excessive stress and a poor diet are also thought to affect sperm So yes, it is worth reviewing your lifestyle to see if improvements can be made Jobs that may expose you to harmful agents, such as pesticides, may also affect sperm, so if you think your partner’s job may pose a risk, it’s worth investigating.
I’m pregnant using a donor -what happens if my child wants to trace her biological dad?
From April 2005, children who were conceived using donor sperm have had a right when they reach 18 years of age to find out their parent’s identity. This also applies to children conceived using donor eggs and embryos. This right applies only to children conceived after this date and not retrospectively. Prior to this date, children had the right to know at 18 years of age if they were conceived using donor sperm, eggs, or embryos and to find out if they were related to someone they wanted to marry. The reason for this change in the law is that children conceived in this way are being given the same rights as adopted children regarding information on their genetic parents. However, some fertility experts fear that this will deter potential donors.
Is surrogacy allowed in the UK?
Currently, surrogacy is legal in the UK, although it is illegal to advertise it as a service However, the law does not recognize surrogacy
as a fixed agreement, which means that a surrogate can change her mind about the arrangement during the pregnancy and up to six weeks after the birth. It is usual for a surrogate to receive ”reasonable expenses”, although there is no definition of what is deemed as reasonable. Usually, this includes costs incurred by the surrogate relating to her pregnancy, If the father of the child is named on the birth certificate, this gives him equal rights to the child. If this is not the case, then six weeks after the birth the new parents can apply for a parental order that gives them full parental status At this point, the surrogate gives up any parental rights to the child.

Conception problems

There are a range of reasons why a couple may have difficulty in conceiving. Investigations and tests may uncover specific conditions, which may be treatable, or you may be offered help to conceive.
What can affect a man’s fertility? A semen analysis may reveal various reasons why sperm have difficulty in fertilizing an egg The sperm count may be low (less than 20 million sperm per ml); the motility of the sperm (how they move) may be poor, and there may be a high percentage of abnormally formed sperm Some men experience a failure to ejaculate at orgasm There may also be damage to the tubes that connect the testicles to the seminal vesicles where sperm are produced, and this may have been present from birth or caused by a later infection
What can affect a woman’s fertility? Conditions such as polycystic ovary syndrome
(a hormonal imbalance that causes ovarian cysts) and endometriosis (see p 19) can disrupt fertility. Other hormonal imbalances, such as low levels of FSH and LH, can affect ovulation; or levels of progesterone may be too low to sustain a fertilized egg. Damaged Fallopian tubes, caused by an ectopic pregnancy (see p 25), surgery endometriosis, or pelvic inflammatory disease, which may be caused by an infection such as chlamydia, can prevent conception. Damage to the ovaries can occur from scarring as a result of surgery or infection, or the supply of eggs may be low Some women have an abnormally shaped uterus, or have uterine scarring, that can prevent the successful implantation of an egg.

IVF treatment

In vitro fertilization or IVF, is a complex procedure with several stages, from the stimulation and harvesting of your eggs to the successful fertilization of the eggs, development of embryos and transfer of the embryos into the womb for implantation. Undergoing IVF can be a stressful and time-consuming undertaking, but knowing in advance how the procedure works and what you can expect at each stage can reduce anxiety and help you and your partner to cope.
What happens first? To optimize the chances of success with IVF more than one egg at a time is removed for fertilization Normally, your body produces one egg each month. In rVF, you will inject yourself with drugs, such as clomiphene and hMG (human menopausal gonadotrophin) to stimulate your ovaries to produce several eggs. While you are undergoing this treatment, you will need to visit your clinic every one to two days over one or two weeks to monitor the development of the eggs. Once it is thought that the eggs are mature, you will be given a blood test to measure your levels of oestrogen, which is released around ovulation.

What happens next? Once your follicles are ripe and ready for ovulation, your eggs will be collected at the clinic using ultrasound or laparoscopy to guide a probe. Once the eggs have been collected, they will be mixed with your partner’s sperm in a Petri dish in a laboratory ready for fertilization Your partner needs to produce the sperm on the same day as the egg collection. He can either do this at home, or come into the clinic with you and produce the sperm while you are undergoing the egg collection procedure.What happens in the laboratory? Once the egg and the sperm have been mixed, they are placed in the laboratory and monitored closely for the next few days. They will first be inspected around 18 hours later to see how many of the eggs have been fertilized and the clinic will usually pass this information on to you the day after the procedure It’s quite common for not all of the eggs to be fertilized and for only two or three to develop into embryos. The fertilized eggs are incubated in the laboratory over the next couple of days and their progress measured. The laboratory technician watches cell division under a microscope, waiting for the eggs to divide into two or more cells on their journey to becoming a blastocyst (see p.21).
If one or more fertilized eggs develop in the laboratory, you will be called back in for the embryo transfer, This is done by injecting eggs through a catheter into the uterus. No more than two eggs will be transferred and you will have the option to freeze any remaining embryos.

Surrogacy
A surrogate mother is a woman who reaches an agreement to carry a baby on behalf of another woman. She can either conceive the baby with the partner’s sperm, in which case she is the maternal mother, or the infertile couple may fertilize their own egg through fertility treatment, which is then transferred into the uterus of the surrogate mother for her to carry the baby through pregnancy and deliver at birth. This process can be beset with problems: such as the conflicting emotions of both the surrogate mother and the receiving couple, or legal issues if, for example, the surrogate mother has a change of heart after the birth and wishes to keep the baby, For this reason, it is important that all parties entering into the agreement have carefully considered the implications and are confident and happy in their roles.