Posts Tagged ‘treatment’

•    Exercise regularly to keep bones strong
•    Take vitamin D along with your calcium supplements
•    Experiment with Menostar (estradiol) instead of hormone replacement therapy
•    Consider Evista (raloxifene) to reduce risks of spinal fracture and breast cancer
•    Ask your doctor about the benefits and risks of Fosamax (alendronate)
•    Make Miacalcin (calcitonin) an option if back pain from fractures is an issue
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We tend to think of our bones as hard and unchanging, like the bones we find on our dinner plate. But actually, they are living tissues that undergo constant change and renewal, just like our other organs. Cells called osteoclasts break bone down, and cells called osteoblasts build it back up, just as if you were remodeling your house a room at a time. The osteoblasts build up living tissue and reinforce it with minerals like calcium, magnesium, boron, and manganese.
Normally, these two processes—resorption and formation of bone—are closely linked so that bone stays strong. Quite a few factors can upset the balance, though. If the osteoclasts race far ahead of the osteoblasts, bone density can drop and eventually the bones are not strong enough. A minor fall can result in a broken hip, which can be catastrophic for an older person.
OStevporosis a condition of weakened bone, is responsible for 1.5 million fractures each year, including 300,000 hip fractureS.71 The National Institutes of Health (NIH) estimates that 10 million Americans currently have osteoporosis. Two million of them are men. While osteoporosis is thought of as a women’s issue, it is not limited to women.
There’s no shortage of controversy surrounding osteoporosis. Perhaps the first issue is just how many people should be RISK FACTORS
•    Female
•    Increased age
•    Shortness and thinness
•    White or Asian
•    Family history of bone loss
•    Sedentary lifestyle
•    Irregular menstrual periods
•    Early menopause
•    Low testosterone (men)
•    High level of thyroid hormone
•    Low-calcium diet
•    Low level of vitamin D
•    Cigarette smoking
•    Alcohol consumption
•    Prednisone or similar drugs (long-term use)
•    Certain anticonvulsants
•    Celiac disease
concerned about it. According to the NIH, 34 million people have low bone density. Add that to the 10 million who have been diagnosed with osteoporosis, and you come up with 44 million Americans for whom “osteoporosis is a major public health threat .,,767 That’s more than half of the population over 50 years of age.
Lumping those 34 million who have low bone density together with those who have already been diagnosed with osteoporosis certainly makes for a larger potential market for the drugs that have been developed to prevent or treat bone loss. Some public health researchers have criticized this tactic by calling it “disease-mongering.’,768 Instead of characterizing osteoporosis or low bone density as a risk factor for fracture, calling it a disease implies that it requires treatment. 769 The critics claim that this tactic mobilizes fear (and helps sell IS IT CELIAC DISEASE?
Anyone can break a bone by falling off a horse or out of a tree. But some people break bones without even trying. If you have experienced fractures for no logical reason, you and your doctor may want to figure out why your bones are not as strong as they should be.
One possible explanation is celiac disease. It should be investigated in young people with low bone density measurements. Celiac disease is due to gluten intolerance. If it is not diagnosed and a gluten-free diet is not followed, the resulting damage to the small intestine can interfere with proper absorption of the nutrients needed to build bone.
drugs) rather than promoting understanding and positive action.
The availability of bone density screening is a two-edged sword in this respect. On the one hand, it is helpful for those who are truly at risk to find out before they break a hip or develop debilitating back pain from vertebral fractures. Unfortunately, many of those being screened are not those who need it most. An analysis of nearly 44,000 women on Medicare found that the oldest women, ages 81 to 85, were only half as likely to be screened as women ages 66 to 70.770 The older women, however, are far more likely to have reduced bone density, even osteoporosis, putting them at risk of a fracture.
Increasingly, middle-aged women are being screened for bone density. The scoring system is a bit complicated, since it is based on standard deviations below the bone density of a young person at peak bone mass. Most of us don’t have the grounding in statistics to make much sense of “standard deviations,” so if the doctor does not explain carefully what the numbers mean, women often end up confused and alarmed. Critics point out that defining osteoporosis as bone density that is 2.5 standard deviations (T score –2.5) below the mean for a young person practically guarantees that approximately 30 percent of postmenopausal women will be diagnosed with this condition, whether they are truly at risk for osteoporosis or not.”Reducing the Risk of Fracture with Nondrug Approaches
Although osteoporosis treatment now includes many more options than it did just 10 years ago, each drug that is prescribed for weakened bones has some drawbacks. That’s why it makes sense to start with nondrug approaches and see how far they will take you. If you begin early enough, you may be able to slow bone loss and prevent a fracture. But even if you already have osteoporosis, these tactics may be a good addition to pharmacological treatment to make it more effective.
Exercise
Your doctor may not be accustomed to prescribing a walk around the block,. but getting more exercise should be just what the doctor orders. In so many cases nowadays we must go out of our way to work up a sweat. Few of us do manual labor to earn a living; walking to our jobs or just to the store is almost as rare, especially in many suburbs. So instead of incorporating physical movement into everyday life, we need to find time—and funds—to go “work out” somewhere.This may be too inconvenient for many people.
It has become clear that our bodies adapt to the demands we make of them. Weight-bearing exercise like walking, running, or mowing the lawn encourages bones to grow stronger.
***** Exercise
Moving your bones helps strengthen them. Doing something enjoyable on a regular basis—walking, gardening, dancing, or another weight-bearing activity—acts to delay bone loss as well as strengthen muscles, benefit cardiovascular health, improve mood, and reduce the risk of dementia. Exercise alone may not be enough to reverse bone loss, but it can improve the effectiveness of other treatments.773
Side effects: Sore muscles
Downside: If the exercise program is overly ambitious or too dangerous, a person with reduced bone density may experience injuries, including fracture.
Cost: Too variable to estimate Sitting in front of a computer screen, sadly, does nothing to stress our bones in a healthy way. In fact, differences in traditional patterns of activity may explain why women usually have less bone mass than men, even as young, healthy adults. In the past, boys were expected and encouraged to be active by playing sports and helping with strenuous chores. Girls, by and large, were not. Although these differences are diminishing among today’s children, physical activity has been declining across the board.
A lifetime of activity is ideal for the strength of the skeleton, but it may never be too late to benefit from more exercise. Anyone who has already experienced fractures from osteoporosis should check first with his or her physician, but appropriate weight training or walking may be helpful even for those who are quite elderly or a bit debilitated. The, exercise program should be carefully designed, of course, so that it does not put the person at a higher risk for fracture from a fall or injury.
The Calcium Craze
Calcium supplements are the first thing most people think of for preventing or treating osteoporosis. Although an adequate calcium intake is necessary to maintain strong bones, just taking calcium doesn’t seem to help very much once bone density has begun to decline. Calcium supplementation can make a difference in young people, whose bones are still developing. But in postmenopausal women, the evidence is murky. Some studies have shown that 500 to 1,000 milligrams of calcium a day together with 700 to 800 IU of vitamin D can reduce the number of fractures (though this benefit does not extend to
the spine ).774,175.776
The results of the Women’s Health Initiative on this issue were less encouraging. The study was very large, involving more than 36,000 postmenopausal women. Though supplements of 1,000 milligrams of calcium and 400 IU of vitamin D daily improved the density of bone in the hip, it did not
3    777
reduce the number of hip fractures, Scientists have tried to explain the disappointing results: The women were not in the oldest age category at highest risk for fracture; the women on placebo pills could take calcium on the side if they chose to; many of the women in the active supplement group did not take their calcium and vitamin D, every day.
Calcium is important for preventing and treating osteoporosis—but by itself it isn’t enough. Taken together with adequate vitamin D, it may help reduce the risk of falling as well as improve bone mineral denSity.77,44
Most of the experts who do research on osteoporosis agree that a calcium-rich diet (or a supplement of around 1,000 milligrams daily) and 15 to 20 minutes of sun exposure 3 or 4 days a week (or a supplement of 800 to 1,000 IU of vitamin D3, also known as cholecalciferol) are a sensible approach. Take no more than 500 or 600 milligrams of calcium at a time for better absorption.
Calcium also works with dietary protein to benefit the skeleton.779 Make sure you are getting enough protein.
Side effects: Gas, intestinal bloating, constipation Downside: Too much calcium increases the risk of kidney stones.
Cost: $6 to $10 per month for a supplement that contains both nutrients
In addition, 400 IU of vitamin D, just may not be enough. An analysis of a number of studies concluded that it takes at least 700 IU of vitamin D, a day to make a difference in fracture risk .780 Lower dosages simply aren’t effective.
Human skin can make vitamin D when it is exposed to sunlight. but older people are often careful not to go out in the
VITAMIN D PARANOIA
The recommendation for supplementing with vitamin D. has been set at 400 IU a day because of worries that a person could get too much. Vitamin D in excess is toxic, so taking more than 2,000 IU a day would be foolish. Most people don’t need a lot more than 1,000 IU daily, but that seems to be a more sensible level to aim for than the currently sanctioned 400 IU. That is especially true for older people at risk for osteoporosis, who may be avoiding sun exposure for fear of skin cancer.
sunshine without their sunscreen. Aging skin is less efficient at making vitamin D, so a health-conscious older person may actually be making very little of it. If this is true for you, a supplement may be advisable.
We weren’t as surprised as others may have been at the lackluster results seen with calcium supplements in the Women’s Health Initiative. Walter Willett, MD, DrPH, MPH, the Frederick J. Stare Professor of Nutrition and Epidemiology and chair of the department of nutrition at the Harvard School of Public Health, had told us years earlier that calcium is not the whole story. Women in Scandinavia have the highest calcium intake in the world, but they also have the highest rates of osteoporosis. Women in some parts of Africa get very little calcium in their diets yet rarely have trouble with fractures as they age. Sun exposure is one obvious difference that might account for women having relatively low levels of vitamin D in Scandinavia.
Clearly, other factors are at work here. That doesn’t mean you should cut down on calcium. But don’t count on it to do the job alone.
If you do choose a calcium supplement, keep in mind that calcium citrate may be taken with or without food, but calcium carbonate is absorbed best if taken at mealtime. 783 Many sources recommend taking 300 to 500 milligrams of magnesium with the calcium supplement.
Drugs to Treat Osteoporosis
Calcium supplements may be necessary but not sufficient against bone loss. Joel Finkelstein, MD, of Massachusetts General Hospital, has suggested that supplements of calcium plus vitamin D should be thought of as the ante for a poker game: It’s the bare minimum if you are going to play.784 Most of the drug treatments for osteoporosis work best if a person gets adequate amounts of these nutrients as well.
Low-Dose Estrogen (Menostar)
Women used to be told that once they reached menopause, they needed to take hormone replacement therapy to keep their bones strong. The idea was that they would be on estrogen (plus progesterone, unless they had undergone a hysterectomy) for decades and that this would prevent osteoporosis and the resulting fractures.
The findings of the WHI threw the wisdom of that simple approach into question. Although hormone replacement therapy (HRT) did cut the risk of hip fracture by more than 30 percent, it increased the risk of coronary heart disease, stroke,
785
and breast cancer. After these findings were released, many women decided that they were more concerned about heart attacks and strokes than broken bones. So they stopped taking their HRT.
Since then, clinicians have been trying to find a way to get the benefits of HRT without all the risks. One way to do that is Menostar is a relatively new ultra-low-dose transdermal estrogen patch. It can increase bone mineral density and has been approved for preventing osteoporosis in postmenopausal women. Menostar comes as a patch applied to the belly. Each one lasts a week.
Side effects: Redness or irritation under the patch. Estrogen has a number of side effects, such as blood clots, stroke, increased risk of breast or endometrial cancer, and gallstones. It is not clear to what degree Menostar will cause estrogenic side effects.
Downside: No evidence that Menostar will prevent fractures; no long-term data on cardiovascular safety
Cost: About $50 a month
with an estrogen-receptor modulator such as Evista (see page 517). Another way might be with a different form of estrogen. In 2004, the FDA approved a low-dose estrogen patch to prevent osteoporosis, This transdermal patch, called Menostar, releases 14 micrograms of estrogen as (17-beta)-estradiol a day. This form of estrogen is different from the mixture found in Premarin or Prempro but the same as that found in some other estrogen pills for postmenopausal women. Estrogen is absorbed well through the skin, so the dosage delivered in a skin patch can be a lot lower than the dosage in a pill.This dose is quite a bit lower than those of other commonly prescribed estrogen patches used to treat menopausal symptoms.”
Menostar is not for treating menopausal symptoms such as hot flashes or vaginal dryness. It is not for use by women who already have osteopOCOSis with vertebral fractures. But for women whose bone mineral density is low or who are at risk for developing osteoporosis, Menostar might be one way to try to get the bone benefits of estrogen while sidestepping the cardiovascular risks.
The research done on Menostar indicates that it is not likely to cause problems in the uterus, even though there is no progesterone in the regimen to protect the uterine lining.” It does increase bone mineral density, particularly in the spine, better than placebo. 718 There are not enough data to indicate whether women using Menostar are less susceptible to fractures, either of the spine or of the hip.
The bottom line on Menostar is that women who choose to use it at this time should recognize that in some respects they are experimenting. There are still some important facts about its potential long-term benefits and risks that need to be clarified.
Raloxifene (Evista)
Raloxifene (Evista) was specifically designed to be as much like estrogen as possible in its effects on bone and unlike estrogen in many other ways. The researchers who developed this selective estrogen receptor modulator, or SERM, were hoping that it would strengthen bone and prevent fractures as hormone replacement therapy seems to, but that it would not increase the risk of uterine or breast cancer as HRT does. They were largely successful in their efforts. This medication does reduce the risk of fractures in the spine, although it does not seem to have much impact on hip fractureS.719
Because any osteoporosis drug must be taken for many years, a study considered the safety of raloxifene over a period of 8 years and found that it did not increase the risk of heart attack, stroke, uterine cancer, or ovarian cancer.7 90 Like HRT, raloxifene increases the risk of blood clots forming in
.,
**** Raloxifene (Evista►
This pill strengthens bone and is especially effective at preventing fractures in the spine. It is approved both for preventing and for treating osteoporosis. In addition, raloxifene can reduce the risk of invasive breast cancer in high-risk (postmenopausal) women by approximately 50 percent.
Side effects: Blood clots, vaginal dryness, hot flashes, joint pain, leg cramps
Downside: Raloxifene does not appear to have a significant effect on hip fractures. In addition, it does not reduce the risk of noninvasive breast cancer.
Cost: Approximately $75 for a month the veins. In fact, this drug increases the risk of fatal strokes as well as dangerous blood clots.19′ As a result, doctors and patients need to weigh its benefits—reducing the risk of spinal fractures and of invasive breast cancer—against the possibility of a blood clot or a stroke.
In the spring of 2006, scientists announced that Evista had performed well in the STAR trial, the Study of Tamoxifen and Raloxifene for preventing breast cancer.The women who had volunteered for this National Cancer Institute–sponsored study were at increased risk of developing breast cancer. Both drugs reduced their likelihood of a breast cancer diagnosis by about 50 percent. Women who took raloxifene were less likely to experience blood clots, cataracts, or uterine cancer than those given tamoxifen.
‘Me investigators concluded that women who had already taken tamoxifen for 5 years following treatment for breast cancer would get no further benefit from taking raloxifene. Women who had not taken tamoxifen but were at high risk of breast cancer could get two benefits—breast cancer prevention and osteoporosis treatment—in one pill if they took raloxifene instead.
Actonel, Boniva, and Fosamax
All three of these osteoporosis drugs fall into the category called bisphosphonates. Alendronate (Fosamax), ibandronate (Boniva), and risedronate (Actonel) work by slowing down bone resorption. They zip to places where bone remodeling is going on and mess with the osteoclasts so that these bone-wreckers work more slowly. Usually, that is enough to give the osteoblasts a chance to catch up a bit on bone formation.
Fosamax was the first bisphosphonate to be developed and approved by the FDA for treating osteoporosis. It has been available for more than 10 years in this country. Women who have taken it for that long have Continued to increase their bone mineral density. Although it was originally prescribed as a once-daily pill, the inconvenience of getting up early enough to take it an hour before breakfast or even coffee and juice, as advised, cut down on its popularity.Taking Fosamax with anything other than plain tap water reduces the amount that is absorbed and lessens its effectiveness. Changing the regimen so that it is taken only once a week, and only half an hour before breakfast, has made it easier for women to follow the doctor’s orders.
The effectiveness of all of the bisphosphonate medicines is clearest in people who are at highest risk: those who already have osteoporosis, particularly those who have experienced one or more fractures. The bisphosphonates are not hormones and don’t work through the same mechanisms as hormones. As a result, presumably they would be equally effective for men and women with osteoporosis.
Many of the studies that have been done on the bisphosphonates involved only women. Among a group of women who’d already had one vertebral fracture, Fosamax cut the number of hip fractures in hal E792 A head-to-head trial of Fosamax against Actonel showed that Fosamax had a slight edge. Subjects taking once-a-week Fosamax had higher bone
*** Alendronate (Fosamax)
Alendronate works by slowing bone resorption. It is commonly given once a week. It must be taken with 8 ounces of plain tap water, not mineral water, at least 30 minutes before eating or drinking anything else. The patient must remain standing or sitting during that time to keep the pill from lodging in the throat, where it can cause damage.
Side effects: Digestive disturbances, including heartburn, esophageal irritation or inflammation that can become severe, stomachache, and diarrhea; severe bone, joint, and muscle pain; osteonecrosis of the jaw, a rare but serious complication following tooth extraction, root canal, and other significant dental procedures; inflammation of the eye, resulting in blurred vision, eye pain, conjunctivitis, uveitis, or scleritis
Downside: Although alendronate has been around for more than 10 years, some of the more worrisome side effects are just now coming to light. No one knows how this drug will affect bone in the long term. Could the increased mineralization of bone end up making bones more brittle instead of stronger? As yet, there are no good answers to this ques- tion.’93
Cost: Approximately $77 per month, a little more than Actonel ($72) and Boniva ($74)
mineral density scores and were less likely to have lost bone than subjects taking once-a-week Actonel. ‘9′
A 3-year study of more than 9,W) women with osteoporosis found that Actonel reduced hip fractures significantly, from 3.2 percent in the placebo group to 1.9 percent in the Actonel group!95′Ibis study found no significant benefit among women who did not actually have osteoporosis but were included because of their age or other risk factors. Boniva, which is given just once a month rather than once a week, can increase bone mineral density. In a study that included nearly 3,000 women with at least one vertebral fracture, Boniva significantly reduced the number of new vertebral fractures.7 It did not reduce the rate of hip fractures or fractures elsewhere besides the spine, however.
A few complications of bisphosphonates that are especially worrisome have been getting significant attention lately. Some people taking Actonel or Fosamax have developed osteonecrosis of the jaw, a condition in which part of the jawbone dies. This seems to be an uncommon side effect, but it is frightening because there is no good treatment for it. Most of the cases reported so far have occurred after tooth extraction or some other major dental procedure. There is no indication that Boniva would be exempt from this issue.
If you are taking any of these drugs for osteoporosis, be sure to tell your dentist and your endodontist about it. We don’t know yet if discontinuing the medication for some months before a dental intervention would reduce the risk of this unusual adverse reaction.
TWo other concerns that have come up with the bisphosphonates are severe joint, bone, or muscle pain, and eye inflammation. ‘Me eye inflammation may affect vision. In one case, 7 the only way to control it was to discontinue the medica- tion. 97 Be sure to discuss your osteoporosis medication with your eye doctor, particularly if you notice any problems with ynx VWion.
The joint or muscle pain required narcotic pain relievers in some cases. The confirmation that it was related to the osteoporosis drug came when drug treatment was stopped and the pain went away—but when the drug was restarted, the pain returned.
Teriparatide (Forteo)
Currently, there is no other osteoporosis drug like teriparatide (Forteo). It is a genetically engineered copy of the active part of parathyroid hormone. This hormone, which is produced by a gland in the neck right next to the thyroid, governs the body’s utilization of minerals such as calcium. Like most of the human endocrine glands, it operates on a feedback system and shuts down when it senses there is enough calcium in circulation. If it senses too little, it stimulates bone breakdown to liberate calcium.
If the hormone stimulates bone breakdown, how can it help treat osteoporosis? Forteo—which is given by injection—is active for only a short time, reaching maximum concentration after about 30 minutes and disappearing completely within about 3 or 4 hours. 799 When the hormone is administered in this kind of short pulse, the body responds by building bone. Forteo is the only osteoporosis drug currently in use that stimulates bone formation.
Studies have shown that Forteo can increase bone mineral density in the spine and the hip. It also reduces fractures in the spine and elsewhere. It performs significantly better than placebo in men as well as women. In a small head-to-head trial against Fosamax, Forteo increased the bone mineral density of the spine by about twice as much and reduced fractures in places other than the spine significantly more than Fosamax did.8w
The FDA has approved Forteo to treat osteoporosis in men and women. It sounds great, but of course there are drawbacks. Side effects with Forteo are mostly mild: nausea, dizziness, headache, and leg cramps. It is given by injection, so redness and swelling may rarely occur at the injection site. A patient just starting on Forteo may experience “orthostatic hypotension,” or dizziness if she stands up suddenly. Fortunately, this side effect usually goes away within a couple of hours.
The big worry with Forteo involves its long-term use. Studies in rats have shown that this drug increases the rate of a bone cancer called osteosarcoma. This may have factored in to the FDA’s decision to limit use of Forteo to 2 years. The medication is so new that no one has a good handle on what the long-term. effects will be, but so far no cases of osteosarcoma have been reported in humans using the drug. 801
Another disadvantage of Forteo is that it must be in-jected every day. It comes in a self-injectable “pen,” and the shot is administered in the thigh or belly. Each pen lasts for a month and needs to be kept in the refrigerator.
In comparison to other treatments for osteoporosis, Forteo is extremely expensive. A single month’s treatment can cost $750 to $800. Given all these negatives, we think Forteo might best be reserved for people whose risk for adverse events with other osteoporosis treatments is too high.
Calcitonin (Miacalcin)
Another hormone that may be prescribed to treat osteoporosis is calcitonin. It, too, is made by the thyroid gland. It binds to osteoclasts and slows down their bone munching. It also helps regulate the action of vitamin D and works together with parathyroid hormone to control the balance of calcium and phosphorus within the body.
Salmon calcitonin can be given either as an injection or in a nasal spray. It can reduce fractures of the vertebrae significantly more than placebo. Some scientists have suggested that it may relieve back pain, which is frequently a serious problem for women whose osteoporosis has caused numerous fractures of the vertebrae. There is no solid consensus on this issue, however. 802,803
** Calcitonin (Miacalcin)
Calcitonin is given not to prevent but to treat osteoporosis. In women who already have at least one fractured vertebra, Miacalcin is significantly better than placebo at preventing additional spinal fractures. Some studies suggest that it helps alleviate back pain by stimulating production of beta-endorphins, the body’s natural opiates.
Side effects: Nausea and vomiting, flushing, redness or soreness at the injection site, rash, reduced appetite, severe allergic reaction; runny nose and nosebleed may occur with the nasal spray
Downside: Expensive. It does not appear to have a substantial effect on preventing hip fractures.
Cost: Nasal spray, $95 per bottle; injection, $45 for 2 milliliters (a 4-day supply)
Conclusions
When it comes to preventing broken hips and painful spinal fractures, there is no single treatment that stands head and shoulders above the rest. Each has benefits and disadvantages. People at risk for osteoporosis will need to think about the issues that might affect their treatment and their ability to stick with the program.
Even when the primary goal is prevention by getting adequate calcium and vitamin D together with exercise (and we strongly encourage that for everyone who can do it), the studies show that nutritional supplements are effective only if people actually take them all the time. Surprise! So consider whether you will take a pill or an injection every day, or if you’re better off with once-a-week or even once-a-month therapy.

NAIL FUNGUS
Over the last several years, nail fungus has garnered public attention completely out of proportion with its seriousness. The medical term, onychomycosis (oh-nick-o-my-CO-sis), is long and scary, but it just means fungal infection of the nail. Perhaps so many people are curious about this topic because nail fungus is very common. In addition, the development of
•    Soak your nails in a solution of one-third vinegar to two-thirds water
•    Prepare a cornmeal suspension and soak nails for an hour a week
•    Apply Listerine to infected nails daily
•    Coat the nails with Vicks VapoRub
•    Soak the nails in tea tree or vitamin E oil
•    Try Pau d’Arco tea soaks
•    Ask your MD about a prescription for urea paste 40 percent to remove the infected nail
•    Apply prescription Penlac (ciclopirox)
•    Consider the pros and cons of Lamisil (terbinafine) and Sporanox (itraconazole)
new antifungal drugs that can treat (dare we say cure?) nail fungus has encouraged the pharmaceutical industry to advertise in magazines, in newspapers, and on television.fbe popularity of sexy sandals as footwear may also have contributed to the interest in treating nail fungus.
For diabetics, nail fungus is a medical issue.fbey need to be extremely vigilant about foot care and attend promptly even to things that may seem minor. For the rest of us, though, thick, yellow toenails that are crumbly or hard to cut are more of a nuisance than a serious health concern. They look ugly, and if they get very thick, they may be uncomfortable as well. Sometimes they split, which can be quite painful.
In our opinion, though, it would be a mistake to put your life on the line to clear up your funny-looking nails. Mat’s why we have collected so many home remedies for this problem. They probably won’t work for everyone, but they shouldn’t be very risky, either.
Q. My husband took Lamisil to treat toenail fungus, The drug worked but was ultimately responsible for his death.
The fine print for this prescription drug noted that it might cause neutropenia. For my husband, it did. This led to MDS (myelodysplastic syndrome), which was followed thereafter by AML (acute myeloid leukemia) and his subsequent death.
He had suffered with periodic flare-ups of toenail fungus and athlete’s foot for most of his life. Neither condition was life threatening. The Lamisil was!
Even though serious side effects mentioned in prescription drug labels may affect only 1 percent of users, anyone could be in that I percent. People should ask themselves if it is worth taking that chancel
A. We are so sorry to hear of your husband’s tragic death. In rare cases, Lamisil may trigger serious blood disorders such as neutropenia, a lack of white blood cells. This drug can also damage the liver; there have been deaths associated with this problem. This is a high price to pay to cure toenail fungus.
Patients must always take into account not only common side effects but also the possibility of rare but deadly adverse reactions.
Home Remedies
It’s hard to say just where nail fungus comes from and why some people appear to be more susceptible than other-, Occasionally readers report that they first noticed nail fungus after going for a manicure or a pedicure. Presumably, it is possible to pass the organism that causes nail fungus from one person to another, and surely from one nail to another.To minimize that likelihood, we suggest that any tools such as scissors or clippers that have been used on a nail that might be infected be soaked in rubbing alcohol for 15 minutes before being used on an uninfected nail.
We think home remedies are the place to start for treating nail fungus, whether it affects the toenails or fingernails. (”This does not apply to people with diabetes, who should seek medical care for this problem.) Needless to say, some doctors are not fond of the idea of using home remedies for nail fungus.
Some time ago, we heard from a podiatrist who was very unhappy with our recommendations. “Home remedies hardly ever work,” he wrote. “The unproven treatments you mentioned are little more than urban legends. In 23 years of practice, I have never seen even one patient who responded favorably to Vicks VapoRub, dilute vinegar soaks, or vitamin E oil. Don’t make me waste time dispelling these myths.” He recommended that people take FDA-approved prescription drugs like Lamisil, Penlac, or Sporanox instead.
We certainly heard from readers who disagreed with him. One person who had success treating nail fungus with vinegar soaks expressed this opinion: “If a treatment is relatively harmless, as this is, and there’s even a chance it can work, I believe doctors should encourage alternative methods instead of high-priced medicines laden with potential side effects.”
A pharmacist also weighed in with some information on the effectiveness of the prescription medications:
I would like to point out some facts about the FDA-approved drugs the podiatrist prefers (Lamisil, Penlac, Sporanox). Does this doctor know that Penlac’s success rate for a complete cure, accord-ing to the manufacturer’s prescribing information, is only 5.5 to 8.5 percent after 48 weeks? When using Sporanox, the percentage of overall success rises to a dizzying 35 percent.
Also, does he know the costs of these medications? A bottle of Penlac costs $72.99. To reach 48 weeks of treatment once a day to a single affected nail, I conservatively estimate that the patient will need six bottles of the lacquer (one bottle approximately every other month), So Penlac will cost the patient, without insurance, 5437.94 to reach an outstanding 8.5 percent cure rate.
For Sporanox, one pulse-pak costs ME99. This is a 14-day supply. The manufacturer recommends 12 weeks of treatment, bringing the patient cost, without insurance, to $1,535.94! No wonder people are looking for alternatives to these medications.
Oral medicines such as Sporanox can occasionally trigger serious reactions as well. No wonder some people are willing to spend time and effort—but not much nioney—trying a low-risk home remedy.
I assumed toenail fungus was a fact of life forme. khad spread to five or six toenails when I finally saw a dermatologist The prescribed treatment was costly, and after it began, the dermatologist told me the odds of reinfection after treatment were about 50 percent
I had a nightmare reaction to the pills a week later I was in remote Finland, of all unlikely places, when I developed hives and severe itching. After 24 hours of nonstop, nonsleep itching, I got through to my doctor and was told to stop taking the pills.
When I got home, / decided to try the vinegar treatment I applied a drop of distilled white vinegar to my toenails with a cotton swab each time I got out of the shower As the nails grew out the fungus was completely gone, along with slight traces of athlete’s foot
Cost: under $ZOO over 9 months.
Side effects: none.
Effectiveness: 1019 percent (or 200 percent it you include the athlete’s foot).
Vinegar
One of our favorite home remedies is a vinegar soak. It is surely, one of the cheapest remedies for nail fungus. People who sit still to read, use the computer, or watch television could soak the foot with the affected toenails or hand with the affected  Vinegar
Use two parts of water to one part vinegar for a soaking solution. It does not seem to matter whether you use white vinegar or apple cider vinegar, so we suggest the cheaper
white vinegar.
Downside: Your toes may smell of vinegar.
Cost: $1.60 to $2 for 64 fluid ounces—enough for at least four treatments, and possibly eight
fingernails in a solution of one part white vinegar to two parts water. Vinegar is acidic, and acid makes the environment inhospitable to nail fungus. Because it is a home remedy, there is no “prescribed” method. Some people have had success soaking for an hour each week, all at one go; others soak once a day; and still others use the technique of daubing undiluted vinegar on the affected nail with a cotton swab every day. Persistence is needed with any home remedy. Nails grow slowly, especially toenails, and you need to give them time to grow out healthy and fungus free.
Cornmeal
Another natural fungus fighter may be cornmeal. We first learned of this approach from a public radio listener: “Put about an inch of cornmeal in a plastic dishpan. Pour in hot water, stir it so the cornmeal gets dissolved, and when it is cool enough not to hurt, soak your feet for an hour. If you do this regularly, it will get rid of the fungus.”
When examining me my doctor noticed that I had nail fungus affecting toes on each foot He recommended that) make a batter by mixing cornmeal and water in a shallow pan, let it sit for an hour, and then soak my feet for an hour He told me to do this once a week for a month. I did the cornmeal therapy for 3 weeks and the fungus was gone. I don’t know why it works, but it’s cheap, harmless, and it worked for me.
We haven’t found any scientific support for cornmeal as a nail fungus treatment, and fewer people have written us regard-Cornmeal
A footbath of cornmeal mush is neither expensive nor dangerous, and it takes just 1 hour a week. Put about an inch of cornmeal in a shallow pan and add enough hot water to dissolve it. Let it cool to a comfortable temperature and soak your tootsies for an hour.
Downside: This treatment could be somewhat messy. Don’t spill it on the carped
Cost: $2 to $4 for 5 pounds of cornmeal—enough for at least five treatments, and probably more
ing their success with cornmeal than with vinegar, but some have used it to eliminate their nail fungus.
Cornmeal does seem to be a popular home remedy in the garden, though. Gardeners claim that working some cornmeal into the soil around a rose bush will discourage black spot disease, a fungus that affects roses.
Vitamin E
We are always impressed by our readers’ ingenuity. We would never have thought of putting vitamin E oil on fungus-infected toenails, for example. We can’t think of a good reason why vitamin E in particular would be useful against fungus, and yet a number of people have tried this approach with some success.
I keep reading about treatments for toenail fungus so I thought I would pass on my solution. When I had this problem several years ago, I used a simple approach. I kept my toenail soaked with vitamin E oil and the fungus disappeared completely. I can’t recall exactly how long it took but it wasn’t too long.
As we understand the vitamin E tactic, a capsule that you would take as a vitamin—any dose will do—is pierced with a needle or a pin.’Iben the contents are squirted out all around the edge of the nail and particularly under the nail, between it and the skin. The key here, as with most nail fungus treatments, is patience and persistence.
Listerine
The old-fashioned mouthwash Listerine is one of America’s favorite all-purpose home remedies. (The other is Vicks VapoRub; more about it in just a bit.) Amber-colored original flavor Listerine contains a mixture of herbal extracts that can fight fungal pasties from dandruff to jock itch. Some people have also reported having good success with soaking infected nails in Listerine.
0. 1 cured my toenail fungus using a fifty-fifty mixture of vinegar and Listerine. I kept the mixture in a quart jar with a screw-on lid and used a clean paintbrush to apply the liquid to the affected toes morning and night. I wore socks to protect the bedsheets at night.
The fungus took about 3 months to clear up. It is slow growing but is also slow to cure. I hope this helps someone else.
A. You combined a couple of favorite remedies. Many people have reported success with soaking infected - nails in one part vinegar to two parts water. Others got good results soaking their toes in Listerine. Such remedies won’t work for everyone and take several months to produce results.
*** Listerine
This amber-colored mouthwash contains a fair amount of alcohol along with a mix of herbal oils including thymol, eucalyptol, methyl salicylate, and menthol. The thymol and the eucalyptol, at least, seem to have antifungal activity, and the other two may fight fungus as well. Soaking the nail in Listerine (original flavor) or daubing on a bit of Listerine after the daily bath has worked for some people.
Side effects: None known
Downside: Your nails may smell like Listerine. Cost: Approximately $5 for a liter  Vicks VapoRub
This ointment contains herbal oils such as camphor, menthol, thymol, eucalyptol, cedarleaf, nutmeg, and turpentine. Some of these have antifungal activity, and they may work synergistically. Apply Vicks VapoRub all around and under the affected nail or nails once or twice a day. Putting it on right after a shower or bath seems to help. If you apply it at night, wear socks to bed to protect the sheets. It may take 6 months to see results.
Side effects: Allergic rash is possible. In addition, we heard from a few people whose fungus-infected nails came off with this treatment. This might increase the effectiveness of the remedy, but it could be painful.
Downside: Inconvenience
Cost: Approximately $12 for 6 ounces. You could probably treat several toenails twice daily for 6 months with this much Vicks.
People have conjectured why Vicks seems to be beneficial against nail fungus. There is a compound in Vicks—thymol—that is now listed as an inactive ingredient.
When I was a premed student at UCLA in 1951, 1 met a mycologist (an expert on fungus). During World War It he devised a preparation to treat fungal infections that were common among the troops in the North African campaign. ft was an ointment that relied heavily on thymol as the most effective antifungal agent and reeked of thyme.
Vicks contains three active ingredients and 22 considered inactive. One or more of these might help thymol penetrate the tissues. I suspect that a pure preparation of diluted thymol, without other ingredients except a solvent, would be a good antifungal nail treatment
Vicks VapoRub certainly does not work for everyone. But we have heard from a great many people who have tried it and gotten a positive response. Some could see the results within a few weeks; others needed to keep applying it for month-s. Even prescription drugs take quite a while to clear toenail fungus, however, because the toenails grow so slowly. The infected nail must grow out completely and be replaced by uninvolved nail.
I had nail fungus fora long time. Medicines recommended by my doctor didn’t work. Then I read about using Vicks VapoRub. I applied it to the nail every day for about 5 months and now the fungus has disappeared. I’ve been cured.
Tea Tree Oil
Tea tree oil comes from an Australian tree, melaleuca. It has long been used to treat skin problems, particularly fungal infections. You don’t need to go to Australia to get it, though. It is marketed widely in stores and on the Internet in the United States. Applying tea tree oil to the infected nails daily can overcome some cases of nail fungus. Some people do develop allergic rashes in response to tea tree oil, however, so be alert for any itching or redness.
Q. Some years ago I was diagnosed with a fungal infection on one toenail. The intense throbbing pain made it difficult to wear a shoe.
My podiatrist said the only way to treat the toenail was to remove it. I had several more months of pain while the toe healed.
After the surgery I was alarmed when another toe showed signs of fungus. I asked about a natural treatment at the health-food store and was told to try tea tree oil.
I applied it liberally several times that day. Within 10 hours, the pain had diminished. I continued using tea tree oil on the nail daily for a few months. The base of the nail grew in pink and healthy.
I am angry that my podiatrist chose to operate on my toenail rather tha” recommend a natural, pain-free tMMYnent.
A. Tea tree oil (derived from the Australian melaleuca tree) has antifungal activity. It has long been used to combat skin and nail problems. Your podiatrist may not know about this herbal product, however.
Pau d’Arco Tea
The lure of the exotic can be seen not only in tea tree oil but also in Pau d’Arco, also called taheebo. This product is the inner bark of a South American tree that has been used medicinally by the natives of Brazil. Argentina, and Paraguay. It contains at least one compound with antifungal activity. Some readers report that using an infusion of Pau d’Arco to soak toenails, much as one would use vinegar or Listerine, can help clear the infection.
Oregano Oil
Oregano oil doesn’t come from a tropical rain forest, but it is hardly a common household staple. Nonetheless, some people have used it topically for fighting athlete’s foot, and others have reported success in using it against nail fungus. Like Listerine and Vicks VapoRub, oregano oil contains thymol. It also contains carvacrol. These two herbal oils together seem to have some antifungal action. Some people are allergic to oregano oil. Anyone who has experienced a reaction to basil, sage, lavender, marjoram, or mint probably should steer clear of oregano oil.
Can you stand another toenail fungus cure? I have found one that works for me, and I have tried them all, including prescription Lamisil pills.
I read somewhere that oil of oregano will kill anything, so tried putting a drop down between the nail and the skin every day. Slowly but surely the toenail is growing out normally! I hope someone else can benefit from this as well.
Lemon
Some years ago, we heard from a reader who maintained that sleeping with a lemon attached to the toe for 3 nights running would clear up toenail fungus. Only a few others have tried this -and reported back to us. It did not work for at least one person, though it seemed to help another.
0 0 *
0. Many people write to you about toenail fungus, but you have never mentioned a remedy I learned from an elderly lady in South Carolina. This remedy requires three fresh lemons. At night cut a hole in the top of one and scoop out a hollow just large enough for the toe.
My mother had a great toenail so thick and hard that she could hardly wear a shoe on that foot. I used duct tape to hold the lemon on Mother’s foot, and put a sandwich bag over it to protect the bed. Do this for 3 nights in a row. The toenail becomes so soft that it can be peeled right off, and the new nail that grows in is normal. It worked for my mother!
A. We have been collecting nail fungus remedies for years, but this is the most unusual. Fungus doesn’t thrive in an acidic environment, which may be why dilute vinegar soaks are so effective. The citric acid in the lemon may work in a similar manner.
Prolonged exposure to pure lemon might be irritating for some people, so we suggest that anyone who wants to try such an approach test it first. Removing a
toenail should be done only with medical supervision,
because there is a risk of infection.
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Prescription Treatments
Unlike home remedies, prescription medications for nail fungus have been scientifically tested and have performed better than placebo. That is the criterion applied by the FDA before approving any prescription product. Don’t expect too much from these medicines, though: They don’t work for everyone, even though they might be more effective than home remedies. Before beginning a prescription medicine for nail fungus, make sure you understand the risks.
Urea Passe
One treatment for toenail fungus is to remove the nail surgically and then treat the underlying skin with an antifungal cream while the nail grows back without fungus. Many people are understandably reluctant to undergo surgery for nail fungus. Infection is always a risk. We hate it when the cure is worse than the condition it’s intended for.
Dermatologists have studied a different approach that is Urea Paste
The high-strength 40 percent urea paste that dissolves infected nails is available only by prescription. Its use should be supervised by a physician who is familiar with the treatment.
Side effects: Irritation, itching, or burning
Downside: Many doctors are not familiar with this approach. Cost: Approximately $75 for an 85-gram tube
far less traumatic. Urea paste at a 40 percent concentration will dissolve infected nail and leave healthy nail alone. It is essential to work together with the prescribing physician, however, as removing a nail is not a trivial issue. Please do not do this at home by yourself.
0. 1 have ugly, thick, yellow toenails that are hard to clip. My doctor says they are infected with fungus but he doesn’t want to prescribe Sporanox because it could interact with other medicine.
I have tried home remedies, including Vicks VapoRub, and none has worked. The podiatrist wants to remove the nails surgically. I know you have written about urea paste to dissolve away the infected nail. Where do I get it and how do I use it?
A. Surgical removal of nails can be painful and there is a risk of infection. Stanford dermatologist Eugene Farber, MD, discovered the urea treatment many years ago while traveling in Russia. 761 Urea (40 percent) is available only by prescription (Ureacin-40, Carmol 40, Gordon’s Urea 40). Your doctor should supervise the treatment.
Penlac
A lot of people are reluctant to take an oral antifungal drug. Some worry about side effects, others are concerned about potential interactions with other drugs they take. Both are valid concerns.
One manufacturer came up with a topical prescription antifungal medicine that is applied like nail polish. Penlac (ciclopirox) was approved by the FDA for the treatment of mild to moderate nail fungus. Like most of the home remedies we’ve already discussed, Penlac requires a lot of persistence. It needs to be applied to the affected nail, including between the nail and the skin, every day. It can cause redness or irritation, and it may take up to 6 months to produce results.
When people use Penlac, they need to see a health-care professional on a regular basis to have any unattached, infected nail removed so it won’t continue to spread the infection. We have no way of comparing Penlac’s effectiveness to that of other treatments. Presumably it is as good as most of the untested home remedies, but it is not really too astonishing. About 12 percent of the patients treated with Penlac in clinical trials were able to clear their toenails of fungus. One of the biggest differences between Penlac and a home remedy is the cost. A little bottle (6.6 milliliters) costs $130 or more.
Sporanox or Lamisil
The heavy artillery for treating nail fungus is an oral antifungal medication. If it is crucial to eliminate the infection, the physician will prescribe a drug such as itraconazole (Sporanox) or terbinafine (Lamisi)). (You may have seen magazine or television ads for Lamisil that feature a cartoon character, Digger the Dermatophyte.)
In a long-term head-to-head study, patients with toenail fungus were given either terbinafine or itraconazole according to the recommended dosing procedure for 3 to 4 months. 762 At the end of that time, 46 percent of the people who had taken Lamisil and 13 percent of those who had taken Sporanox had no detectable fungus in their nails. The follow-up extended for another 4 years or so. The investigators (some of whom worked for the maker of Lamisfl) found that relapse rates were significantly higher among those who had taken Sporanox.
An analysis of cost-effectiveness found that terbinafine is the most cost-effective treatment a doctor can prescribe. 761 Penlac was judged to be at least three times more expensive than the others, considering cost per cure. This analysis did not take any of the home remedies into account. If there were scientific data on them, they might well demonstrate low effec-tiveness, but because they are cheap, their cost-effectiveness might compare well to some of the standard treatments.
Another advantage of home remedies is the low likelihood of serious side effects. Lamisil is considered fairly safe, even for children and the elderly.764 Nonetheless some people taking Lamisil have developed liver failure.’W~ People who already have liver problems should not be given this drug. Other people taking Lamisil have come down with a very serious skin reaction, so anyone who develops a rash should get in touch with the doctor promptly. People who have lupus could get worse while taking Lamisil, so it’s generally not recommended for them.
As we mentioned at the beginning of this discussion, Lamisil occasionally can lower white blood cell counts to dangerous levels. Usually, the count comes back up once the person stops the drug. This drug may interact with other prescription medicines, including antidepressants. beta-blockers, and certain other medications that regulate the heart’s rhythm. By now, we hope we have convinced you to stay in very close touch with the doctor who prescribes Lamisil for your toenail fungus. It’ll probably run you more than $800 for the 12 weeks of treatment, but because it works so well, it is quite cost-effective.
Conclusions
Nail fungus, particularly toenail fungus, is usually more of a nuisance than a serious medical problem. (For diabetics, however, nail fungus or any other foot problem qualifies as serious and requires medical care.) As a result, we feel comfortable in recommending that most people try home remedies first. We don’t have any data on how well they work, but the testimonials we have received indicate that they do work for some people. In addition, they are inexpensive and don’t cause dangerous interactions or reactions.
A palm) who needs a higher likelihood of cure may need a prescription for Lamisil. It is the most cost-effective of the prescription nail fungus drugs. Even so, it does not work for everyone, and it is not always appropriate. Some people may be taking other medicines that could interact with Lamisil. Others may be at risk of liver problems or complications such as lupus. Most of the time, nail fungus is a problem you can live with; some of the rare side effects could be deadly.
•Toenails grow slowly. It takes a year to a year and a half for them to grow out completely, so be very patient and persistent.
•    After cutting fungus-infected nails, soak the clippers or scissors you used in alcohol for 15 to 20 minutes so you don’t spread the infection.
•    Soak your feet in a footbath of one part vinegar to two parts water for 20 minutes a day.
•    Mix cornmeal with hot water, allow it to cool to a comfortable temperature, and soak the affected nails for 1 hour once a week for at least a month.
•    Squeeze vitamin E oil or tea tree oil around the cuticle and under the nail once or twice a day.
•    Soak the feet in original Listerine or apply it daily to the affected nails.
•    Smear Vicks VapoRub around and under the nail every day.
•    Brew an infusion of Pau d’Arco for soaking the affected nails every day.
•    Stick your toe in a lemon overnight to soften the infected nail for removal.
•    If the nail needs to come off, ask your doctor about prescribing urea paste (40 percent).
•    Lamisil is the most effective prescription pill for fighting nail fungus.

MENOPAUSE
*Turn the thermostat down to reduce hot flashes
•    Use the lowest-dose estrogen and progesterone therapy for the shortest time possible
•    Try Remifemin for hot flashes    ***
•    Eat tofu or tempeh or drink soy shakes    **
•    Ask your doctor about Paxil (paroxetine) or Effexor (venlafaxine) for hot flashes
•    Inquire about Neurontin (gabapentin) for hot flashes
•    Apply olive oil topically for vaginal dryness
•    Squeeze vitamin E out of a capsule as a sexual lubricant
•    Experience slippery sex with Sylk
•    Experiment with aloe vera gel
•    Get a prescription for Estring (estradiol)    ***
Decades ago, menopause used to be referred to in whispers as The Change. The mystery surrounding the event gave it a sinister aura. Now, though, more than 5 000 women enter menopause every day in the United States. ~21 That’s because the baby-boom generation is aging. We are not a bashful bunch, and female boomers have brought menopause out in the open. Women refer to hot flashes, somewhat jokingly, as power surges. But few women relish them. Most would like some way W ease this symptom, even it it is the consequence of a perfectly natural biological process.
We ought to begin with some explanation of menopause. Most people know this refers to the time when a woman’s ovaries stop making the hormones that support the ripening and release of eggs. It is a gradual process that may be spread out over years, perhaps even a decade, and is properly referred to as perimenopause. Menopause itself is technically just one point in time: the day when an entire year has passed since the end of a woman’s last menstrual cycle.722 The average age on this day is 51 years, but women may be as young as 40 or as old as 58 and still be within the normal range for menopause.
Just as the timing of this change in ovarian function differs from one woman to another, so do the timing and intensity of menopausal symptoms (yes, we should be calling them perimenopausal symptoms). Some women barely notice a hot flash or two. We’ve even spoken with women who had “cold flashes” rather than hot flashes. Others are distressed by intense heat waves that may plague them daily for years. Most fall between those extremes but would still welcome some respite from the sweating, the flushing, and the distracting feeling that they might spontaneously combust. (Not to worry—that has never happened!)
I hope you can recommend something for my wife, who feels like she is about to burst into flames. Her doctor suggested Premarin, but she refuses to take it because she is worried about the increased risk of breast cancer What other options are there?
If it is any comfort, this period of discomfort lasts about 4 years, on average. That means, though, that some women zip through it much more quickly, whereas others take longer, sometimes much longer, to get through to relief.
The Hormone Controversy
For years, women suffering from hot flashes and other menopausal discomforts were told that their doctors had the magic solution: Just take hormones to replace the ones their ovaries were no longer making. Hormone replacement therapy, or HRT, has had its ups and downs over the decades, beginning with Premarin’s approval in 1942. Since then, more than 30 billion doses of this h101MIOnt di Wled from pregnant mares’ urine have been dispensed.
When doctors discovered that women taking Premarin were at greater risk of developing cancer of the uterine lining, this prescription went out of vogue for a while. But then researchers found that adding progestin, a synthetic form of progesterone (usually prescribed under the brand name Provers), could reduce this risk. In the 1990s, Premarin became the most prescribed pill in history. Besides easing hot flashes,night sweats, and other menopausal problems, HRT was supposed to save women’s lives by reducing their risk of heart disease, colon cancer, osteoporosis, and other serious health
threats.
These days, though, the story has changed, and a lot of menopausal women are feeling confused and betrayed. For years, they were told that they were suffering from an estrogen deficiency syndrome. Replacing the hormones their bodies no longer made was supposed to ease menopausal symptoms. Women who resisted a prescription for HRT were sometimes treated as difficult cases. Some were told that though HRT might raise the risk of breast cancer, it was a much less significant concern than heart disease, which HRT might protect against.
After I was operated on for breast cancer, I was told that I could no longer take estrogen, because my tumor was ‘estrogen-dependent’ My primary physician actually had the gall to tell me: The benefits of estrogen far outweigh the threat of breast cancer, and besides, we can cure breast cancer’
Women have a right to be furious. The hormone hype that lasted for several decades represents one of the biggest scams in modern medicine. Millions of women were guinea pigs in an uncontrolled experiment. Physicians who pride therpselves on practicing “evidence-based medicine” prescribed drugs that were unsupported by data. Many women who expressed their fears to their physicians were told in no uncertain terms that the benefits of HRT outweighed the risks.
When the National Institutes of Health announced a huge, long-term study of hormone replacement therapy, advocates of HRT were thrilled. They anticipated that the best available science would support their convictions that HRT had many health benefits, far beyond simply easing hot flashes. Thousands of women were recruited to the study and randomly assigned to take either Prempro or a look-alike placebo pill.
When the results of this study—called the Women’s Health Initiative (WHI)—were announced in 2002, many physicians were surprised and women were shocked to learn that instead of protecting women from heart disease and cardiovascular complications, HRT actually increased their risk. A few doctors had anticipated that the study might show an increased risk of breast cancer. As early as 1995, the Nurses’ Health Study, which followed more than 100,000 women, had confirmed that estrogen replacement therapy significantly increased the risk of breast cancer in postmenopausal women and demonstrated that progestin did not diminish that risk 723 If anything, the data suggested that adding progestin could increase the risk .721
Although there had been hints from previous research that estrogen, with or without progesterone, might increase a woman’s risk of breast cancer, such concerns were mostly downplayed. Opinion leaders reminded physicians that the leading cause of death in postmenopausal women is heart disease. (Breast cancer  comes in second.) Some eminent gy- necologists opined that if breast cancer was a risk, it was a minimal one, associated only with long-term HRT use. Such cancers were thought to be “good” cancers in that they were “early” cancers, easily detected and treated and not associated with increased mortality.
Further results from the WHI gave the lie to that claim. The investigators found that women taking combined HRT (Prempro) were more likely to be diagnosed with breast cancer than those on placebo and were more likely to have invasive, more advanced cancers. They concluded, “These results suggest estrogen plus progestin may stimulate breast cancer growth and hinder breast cancer diagnosis.”115
As a result of these new findings, doctors may also be feeling betrayed. They too were sold a bill of goods that did not turn out to be as advertised. It is now clear to all that HRT is not a panacea for the miseries of menopause. But what remains unclear is exactly how women should cope with hot flashes, night sweats, sleep disruption, and vaginal dryness. Finding out that estrogen doesn’t really prevent heart disease still leaves women with plenty of options for reducing their risk of heart trouble. And there are other possible treatments for osteoporosis, another condition for which women were given long-term estrogen treatment. But what can be done for those annoying, sometimes debilitating hot flashes?
Alleviating Hot Flashes
Certain simple lifestyle adjustments might be all that some women need to make hot flashes tolerable. First, turn down the thermostat. This seems too simple to work, but many menopausal women are less uncomfortable when the temperature is cooler.726 Second, dress in layers that can be easily removed. ‘Ibis is simple common sense.Third, follow the Southern belles’ example and keep a fan and a nice coot (nonalcoholic) drink handy. Fourth, keep exercising. Or if you are not already walking, swimming, or dancing, start. It’s not a miracle, but women who exercise regularly seem to have fewer hot flashes or find them less bothersome. Besides, exercise eases depression and anxiety and is beneficial for the heart and the bones as well.
Hormone Replacement Therapy
When it comes to taming hot flashes, estrogen is undeniably the gold standard. Estrogen, either alone or in combination with progestin, clearly reduces the frequency and severity of hot flashes by about 75 percent.727 This is significantly better than placebo, although women with hot flashes are susceptible to the placebo benefit.
In most studies of HRT or herbal alternatives, women taking the placebo had nearly 60 percent fewer hot flashes per week at the end of the studies, on average, than at the beginning. 721 Women on HRT, either estrogen alone or estrogen together with progesterone, also seem to have less trouble with night sweats that awaken them and disturb their sleep. There’s little evidence that herbal treatments have much effect on menopausal sleep problems, which many women find extremely disdirbing.
If it weren’t for the WHI, doctors would still be prescribing Prempro (a combination of Premarin and Provers) to virtually every menopausal woman who would take it. And they would still be encouraging women to keep taking it long after menopausal symptoms faded away, as a general-purpose “health and beauty aid.”
The characteristics of the women who were willing to use HRT before the WHI results were available probably accounted for many of the benefits seen with HRT in earlier, observational studies. Women were told that HRT was good for their health, so those who chose to take it were more likely to be the health-conscious, careful eaters, regular exercisers, nonsmokers, and occasional drinkers. Their healthy behaviors, rather than the HRT per se, are now believed to be responsible for their lower rates of heart attack, stroke, and many other problems.
The WH I put the issue of HRT and heart attack prevention to  Estrogen and Progesterone
Hormone replacement therapy reduces hot flashes significantly for most women. Women who still have a uterus need to take progesterone along with estrogen to protect themselves from endometrial cancer.
The risks of this therapy rise significantly at 5 years of use. For most women, intense hot flashes last less than 5 years. Ask for the lowest possible dose, and increase the dose only if that does not adequately relieve the hot flashes and night sweats. Hot flashes may return if HRT is stopped abruptly, so gradually tapering off it may be more successful. Transdermal estrogen (Climara, Estraderm) may be less likely to trigger nausea, but there haven’t been good headto-head comparisons.
Side effects: Breast tenderness, nausea, gallbladder problems, migraine headaches, intolerance to contact lenses, elevated blood sugar. If progesterone is given only 1 week a month, vaginal bleeding resembling a menstrual period is common.
Downside: HRT increases the risks of breast cancer and blood clots that could trigger heart attacks and strokes. These risks increase over time. HRT should be used only as long as it is needed for perimenopausal symptoms.
Cost: Approximately $40 to $75 per month for brand-name HRT; generic is available for $12 to $20 per month
the test with more than 16,000 postmenopausal women. Unfortunately, HRT did not pass. Women who had never undergone hysterectomy were randomized to Prempro or placebo, but the study was stopped early when it appeared that the women taking HRT were at greater risk than those on placebo .129 Although Prempro had been expected to protect women from heart attacks and strokes, the results showed that women taking this HRT were nearly 30 percent more likely to develop coronary heart disease and twice as likely to come down with a pulmonary embolism, a dangerous blood clot in the lung.730
None of this has much bearing, though, on the use of hormones to treat hot flashes. The risks are primarily for women who take Prempro or other forms of estrogen and progester-one for extended periods of time.The most recent recommendations, based on subanalyses of the WHI data, suggest that women just entering menopause (ages 50 to 54 in particular) may be more resistant to the dangers of estrogen and might even get some protection from heart attacks by taking it. 31 Short-term use (for a few months up to a couple of years) to get through the worst of the hot flashes doesn’t seem to pose an excessive risk for most women. Those who have previously had dangerous blood clots or breast cancer or who have a strong family history of breast cancer should probably avoid estrogen even in the short term, however.
O. 1 took hormones for 4 years and then discontinued them for a year. Now I have started again, at the urging of my doctor. While I was not taking hormones, I had hot flashes, night sweats, and vaginal dryness.
I stopped taking hormones because the progesterone component made me irritable and depressed. (I was taking Premarin and Provera.) My doctor put me on Estrace and Prometrium this time, but I still feel prickly and sad.
I’m convinced progesterone is the problem, so I wonder if I can take the estrogen alone. I recently read that estrogen has heart benefits.
A. The hormone controversy has heated up again. A study showed that women between the ages of 50 and 59 taking estrogen alone were not at increased risk of heart attacks (Archives of Internal Medicine, February 13, 2006►. These women had previously undergone hysterectomies, so they did not need progesterone.
Estrogen alone is not safe for a woman who still has her uterus since it increases the risk of endometrial cancer. Progestins like Provera protect against this kind of cancer. When added to estrogen, however, they may increase the risk of heart attacks and strokes and possibly breast cancer as well. For some women, progesterone lowers libido and leads to depression.
Doctors have followed the practice of prescribing progestin along with postmenopausal estrogen for many years, since research determined that estrogen alone increased the risk of cancer of the lining of the uterus (the endometrium). Endometrial cancer is not an issue for women with no uterus, and in the WHI study, these women were randomized to Premarin (estrogen alone) or placebo. This works just fine for hot flashes. Don’t count on it to provide any cardiac benefits, though. Overall, women in the WHI study were not protected from heart attack or stroke by HRT whether they took Prempro or Premarin alone.32
Some critics of the WHI have objected to the use of Premarin or Prempro, and suggested that other forms of postmenopausal estrogen replacement therapy would be preferable. There aren’t studies to prove or disprove that idea. Epidemiologists at Group Health Cooperative, a big health maintenance organization in Washington, compared rates of heart attack and stroke among women taking Premarin and those taking another form of estrogen such as Estratab or Menest. They found a hint that the other forms of estrogen might be somewhat less likely to trigger a heart attack or stroke, but these data need to be confirmed.733
Bioidentical Hormones
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Q. I am a family physician. Back when we were prescribing HRT regularly, I used to offer women the option of plant-based estrogens instead of synthetic hormones. Since we learned the results of the Women’s Health Initiative (WHI), though, I’ve viewed all estrogens as carrying similar risk until proven otherwise.
There are practitioners who are saying that bioidentical hormones are safer. They encourage women to use them as an alternative for treating menopausal symptoms. Is there any research that shows that the risks are lower for plant-based HRT than for synthetic?
A. There is no comparable study of plant-based estrogens, and there is not likely to be one. The WHI was a very large and expensive study funded by the National Institutes of Health. Women were randomly assigned to receive Prempro or placebo. The results showed that postmenopausal hormones increased the risk of breast
cancer, heart attack, and stroke.
Women’s health expert Susan Love, MD, responded
to a question like yours: “I think that it is very unlikely that bioidentical hormones, as they’re called, will be any safer than Prempro.”
0 * *
The American College of Obstetricians and Gynecologists (ACOG) came out with a very strong caution about bioidentical hormones in 2005. Michele Curtis, MD, is associate professor of obstetrics and gynecology at Houston’s University of Texas Medical School. On behalf of ACOG she said. “There are a growing number of women who are seeking therapy with bioidentical hormones, but there is a lot of misinformation about the assertion that these are plant-derived and therefore more closely mimic the estrogen that is in a woman’s body….. These are hormones. They act just like estrogens that are 34    commer-
cially produced.,,7
The obstetricians and gynecologists of ACOG are concerned that plant-based hormones are unregulated and, as a result, women may not be informed about risks. In addition, lack of oversight may mean that it is hard to guarantee quality. Many of these products are made in small compounding pharmacies that act like micro–drug companies but escape the kind of regular FDA inspections one might expect a bigger manufacturer to undergo. When the FDA did check on samples from 12 compounding pharmacies, ACOG reports that “34 percent of them failed one or more standard quality teStS.!,131
Progesterone
Kau Nwmnwe intrigued by the possibility that a progesterone cream derived from plant sources can be applied to the skin to relieve hot flashes naturally. Although wild yam can be used as a raw material for the manufacture of progesterone-like compounds, the human body can’t convert wild yam to progesterone. A controlled study suggests that a cream containing wild yam extract is not much better at reducing hot flashes than a placebo.736 Other creams formulated to contain progesterone can provide a dose comparable to taking progesterone by mouth.”‘ Progesterone pills or long-lasting injections such. as Depo-Provera can ease hot flashes, but questions remain about the long-term safety of this hormone for postmenopausal women. 738
0 0 0
0. A nasty divorce has left me feeling slightly depressed, despite the relief of being out of a bad marriage. At times my heart races and then I break out in a sweat. I don’t know if these episodes are just anxiety or if they are hot flashes, since I am menopausal.
I am reluctant to take estrogen because I’ve heard about negative effects. IV rather use a more natural approach. Would a progesterone cream be safe?
A. Many women experience hot flashes much as you have described them, with an accelerated heart rate, a vaguely anxious feeling, sweating, and feeling too warm. Progesterone cream may help reduce hot flashes. Women’s health expert Susan Love, MD, points out, however, that high levels of progesterone are not natural after menopause. She worries that potential side effects might arise with long-term progesterone use. In addition, progesterone has been linked to depression.

Sleepy-Time Smells
Smelling yourself to sleep seems like a pretty strange concept macrodantin doses . We have to admit that aromatherapy for insomnia seemed like a stretch to us, too metabolising caffeine . Most people are used to swallowing medicine, not smelling it nizoral anti-dandruff shampoo . Nevertheless, scientific research supports the idea that soothing smells may be relaxing and actually enhance sleep chronic daily headache tizanidine .69′ Lavender and jasmine are the two scents that seem to promote sleep half life of cymbalta . Sleep researchers at Wesleyan University in Middletown, Connecticut, found that lavender increased deep sleep in both men and women paroxetine formula . and they concluded that lavender aroma has sedative and sleep-promoting activity albuterol swollen epiglottis .691
Some people put a sachet u”dty their pillow is metformin a sulfonylureas . Others spray 1hle pillowcase with scented sandoz recall toprol . water metronidazole fish treatment .
Several friends and I have discovered a wonderful natural way to help insomnia zocor and muscle breakdown and pain . It is called “lavender and vanilla pillow mist” It can be purchased at the bath shops found in a shopping mall hyzaar astra zeneca .
When I first heard a friend tell me that she had been using sleeping pills for several years, and then did not need them once she discovered the lavender pillow mist, I originally thought it was all in her head using doxepin in treating ezema . But I gave it a try and found it most relaxing wall street journal zocor .
You just spray a little on the corners of your pillow, where your face will be isotretinoin substitutes . It even seemed to help my stopped-up nose!
To brag a little more, I sprayed some on my dog’s pillow, and she slept about an hour longer in the morning can viagra be taken with norvasc . I have been told that the Egyptians have used lavender for relaxing for more than 500 years mix bendryl claritin . Perhaps this will help those who are having insomnia and want a natural way to go to sleep amiodarone hcl wikipedia .
Those who don’t find lavender appealing may want to consider jasmine instead order cheap ranitidine . Researchers at Wheeling Jesuit University compared sleeping environments infused with jasmine, lavender, and no smell at all achat libre viagra . Twenty subjects were tested for 3 nights each and then given mental function tests price pseudoephedrine . Those who slept under the influence of jasmine woke up more refreshed and alert duloxetine torrent pharma . They scored better on the tests by responding more quickly and accurately grand mercure apartments allegra hervey bay . Lavender also seemed to help, but not as much as jasmine arava folic acid .69′ Scientists have found that both jasmine and lavender odors have measurable effects on nerve activity, mood, and heart rate caffeine addiction physical addiction . 693 A caller to our national radio show also reported that the scent of eucalyptus helped her sleep asprin asa classification .
Breaking the Vicious Pill Cycle
It may be difficult for people with chronic sleep problems to break out of the medication merry-go-round flomax litigation . Anyone who has relied on sleeping pills like diazepam (Valium), lorazeparn (Ativan), or temazepam (Restoril) will discover that stopping suddenly may lead to several sleepless nights topical ethynyl estradiol . Often, this sets in motion a vicious cycle in which the insomniac reverts to the medication just to get a little sleep but finds once again that when he or she stops the medicine, rebound insomnia kicks in how long diflucan stays in system .
It is not likely that natural sleep aids will be able to counteract this effect timing intercourse while taking clomid . Instead, you may need to discuss such a drug dependency problem with your physician to develop a withdrawal strategy buy promethazine . It may take several weeks (or longer) to wean yourself off a traditional sleeping pill habit wellbutrin overnight . Once “clean,” though, it may be possible to substitute an herb or a dietary supplement to get a decent night’s sleep without creating another vicious circle of rebound insomnia nutrients that lipitor diminishes . Because melatonin is a natural chemical created in the brain and is essential for normal sleep, it seems logical that taking melatonin in a pill would be helpful for insomnia synthroid or armour thyroid . Many peo- ple believe that melatonin is a wonderful natural sleep aid tadalafil no consultation . Unfortunately, the studies that have been done have produced mixed results comparison between effexor and lexapro . One careful review of clinical trials concluded, “There is evidence to suggest that melatonin is not effective in treating mostary sleep disorders with short-term use (4 weeks or less) azor olmesartan .”694
People taking melatonin did fall asleep more quickly-11 minutes on the average—not enough to write home about affect allegra d side . ‘Me authors concluded that melatonin appears to be safe, at least in the short term uses of triamcinolone acetonide . Another meta-analysis of 17 sleep studies reached a different conclusion diflucan works in 24 hours . Those investigators found that melatonin reduced the amount of time it took for people to fall asleep and increased the amount of time they spent sleeping flagyl avntis .’95
‘Me one condition for which melatonin appeared to work well is “delayed sleep phase insomnia aldactone and male pattern balding .” People with this problem go to bed very late (perhaps 3:00 or 4:00 a withdrawal schedule for prozac .m prandin percent compostion of carbon .) and get up late (around 10:30 a information on drug spironolactone .m does paxil raise cholesterol level . or later), haye trouble going to sleep at a normal time, and experience morning grogginess medicine called aleve . “Taking 5 milligrams of melatonin 3 to 4 hours before bedtime allowed such people to go to sleep more easily around midnight diflucan for diabetes .
** Melatonin
Taken 30 minutes before bedtime, melatonin may help a person get to sleep faster and improve sleep quality vermox contraindications . The dose is controversial 2d6 enzyme produce tamoxifen . As little as 1/3 milligram (300 micrograms) may be optimal (this dosage is available from Nature’s Bounty) crying while on alesse . Most supplements provide 3 Milligrams, which is DTDbably too much compare claretin and allegra .
Side effects: Tiredness, dizziness, headache orthostatic hypotension warfarin . Don’t mix with warfarin (Coumadin) demeclocycline for sale .
Downside: Finding 0 weight loss hair loss finasteride .3-milligram doses is hard online pharmacy soma no rx . You may have to split a 1-milligram tablet three ways low female testosterone .
Cost: Approximately $2 to $3 for a month’s supply
Melatonin
Acupressure
We never considered acupressure a viable sleep aid until we received a most unorthodox home remedy from one of our readers converting from coreg cr to coreg . He suggested taping a dried bean to the inside of the wrist between the two tendons risperdal law prolactin . He measured three finger-widths from the crease of the wrist lumiracoxib naproxen chan . The point he described is known in traditional acupuncture as the Inner Gate altace online . Pressing on it is supposed to relieve anxiety, slow the heart rate, and promote sleep cialis does it work for everyone .
I read in your column about an acupressure point on the inner arm to aid sleep viagra how long side effects . You suggested taping a kidney bean between the two tendons, three finger-widths from the wrist mefloquine and pregnancy .
My husband and I tried it, and it’s been amazing! The tape was uncomfortable on our skin, so we’re using plastic “marbles” (for arranging flowers in vases) instead of a kidney bean, and we secure it with an elastic hand cozaar hypotension at night . ft has improved our sleep tremendously, and we wanted to thank you ortho micronor birth control .
Other ingenious readers devised wristlets with buttons to exert pressure on the proper point what causes multiple pregnancies clomid . Apparently, though, the acupressure point our reader described is not the only one that could be used cipro hc otis dosage . A commercial product, 1st Choice Sleep Band, from the makers of Acuband, exerts pressure at a spot on the heart meridian (Ht7) metformin sodium . The manufacturer claims that wearing the bands on both wrists promotes restful sleep (for more information, go to www do robaxin and naprosyn contain aspirin .acuband mirtazapine dose sleep .com) taking zoloft and luvox together .
There is relatively little research to support acupressure for treating insomnia prednisone cancer pain . Not surprisingly, most of what there is has been done in places where people are familiar with the concepts behind acupuncture and acupressure cialis affiliate program . A Korean study found that acupuncture of the ear assisted elderly people in getting to sleep engles urso follmer .697 A Taiwanese study found that acupressure improved the quality of sleep in older people what is avodart side effects .698
Herbal Solutions
Compared to pharmaceuticals, herbs get no respect cocker spaniel skin yeast ketoconazole . Physicians think they are wimpy at best and ineffective and dangerous at worst ibuprofen combined with . This is despite the fact that the sleeping pills they have prescribed for decades carry substantial risks of their own abilify and adhd . More about sleeping pill problems in a moment,though suzanne sommers estrace 2mg . The question is whether it would even be worth trying an herbal approach to insomnia side effects of stopping prednisone .
VALERIAN (VALERIANA OFFICINALIS)
Do you remember the story of the Pied Piper of Hamlin? He used music to rid the town of a rat infestation diflucan dosage ringworm . Some herbal experts suggest that he may have used valerian as well arms ache on prednisone . It was popular in medieval times to flavor soups and stews blood pressure ibuprofen . Because dried valerian root smells like sweaty socks or stinky cheese, presumably the aroma would be appealing to rats wellbutrin xl 300mg generic . Some even suggest he could have given valerian to the town’s children to quell their fears before playing his pipe for them lithium 9v duracell . That would have made it easier for him to lure them away after the town fathers refused to pay him what they owed him for ridding the town of rats sides effects prozac .
Regardless of whether this legend has any basis in fact, the herb has long been used as a mild sedative prilosec compaired to aciphex . A number of small trials suggest that valerian reduces the amount of time it takes a person to fall asleep and may improve the quality of sleep how much does prozac cost .699 In one 6-week study, standardized valerian extract proved just as effective for mild insomnia as the Prescription sedative oxazepam (Serax) lithium’s alchemists symbol . Do not expect valerian to work instant magic amoxicillin clavulanic dose for pig . Unlike traditional sleeping pills, it appears that valerian is more effective when taken nightly for at least 2 weeks alprax caverta calcutta drug .
The biggest advantage of this herbal approach over antihistamines like diphenhydramine (Benadryl or Tylenol PM) and prescription sleeping pills like tema7epam (Restoril) is that va-
*** Valerian
Taken 30 minutes to 2 hours before bedtime for at least 2 weeks, valerian can help a person get to sleep faster ranitidine . It may also improve sleep quality drug interaction valium and prilosec . The dose is 300 to 600 milligrams daily neurontin for children . For tea, use 2 to 3 grams of dried root and steep for 10 to 15 minutes penicillin aqueous .
Side off ects: Digestive upset, rare headache muscle builders with testosterone . Don’t mix with prescription sedatives such as barbiturates or benzodiazepines discount viagra furthermore cheap adipex reviews .
Downside: Smells bad; quality variable
Cost: Approximately $8 to $12 for a month’s supply lerian does not affect coordination or make you woozy celebrex attorneys pennsylvania .100 This is critical if you wake up in the middle of the night to go to the bathroom ndc for toradol . Anyone who is a little unsteady could fall if taking standard sleeping pills discontinuing 300 mg tegretol .
OTHER SLEEPY-TIME HERBS
Other herbs that people have used to treat insomnia include hops, chamomile, lemon balm, passionflower, St withdrawal symptoms from effexor xl . John’s wort, kava, and fennel seeds hyzaar 50 12.5mg . There are, unfortunately, few large, randomized, controlled studies to verify the effectiveness of any of these natural prodUCt&70′ Kava works, but concerns have been raised that it might cause liver toxicity california discount pharmacy tramadol .This may have to do with how the kava is manufactured, but until this issue is resolved, we cannot recommend the long-term use of this herb purchase and viagra soft .
Chamomile tea is what Mrs lexapro cramps . Rabbit gave Peter to ease his tummyache and help him get to sleep after his mischief in Farmer MacGregor’s garden can i take reglan being pregnant . (In one of her other books, Beatrix Potter suggests that lettuce can make little rabbits sleepy, though she doesn’t find it affects her that way prozac reduce headaches .) Chamomile has traditionally been suggested to be a very gentle sedative, but there is hardly any evidence that it would have an effect in insomnia paxil ativan . On the other hand, a cup of chamomile tea might settle the stomach and be a nice way to calm down before climbing into bed wellbutrin for percocet withdrawl .
Sleeping Pills
Like Rip Van Winkle, the sleeping pill business is waking up after a long period of hibernation name of man who discovered penicillin . During the 1990s, sleeping pills fell out of favor coumadin activated . Triazolam (Halcion) was extremely popular after coming on the market in 1983 imipramine pm . Here was a sleeping pill that worked quickly to put people to sleep and would not leave a morning hangover like its predecessors (Dalmane finasteride and proscar cheap . Restoril, or Valium) does acai have caffeine . Since the, drug was rapidly eliminated from the body, it was believed to have no measurable effect the following day actress in viagra commercial . Halcion quickly became the market leader herbal med comparable to lasix .
Then odd reports started cropping up paxil treating delayed orgasm . Scientists taking Halcion to prevent jet lag while traveling to international conferences noted bizarre lapses in memory concerning events that happened the following day periactin to treat nausea . These people appeared normal to friends and relatives while they were giving speeches, recovering lost luggage, and sightseeing the day after taking Halcion amoxicillin with milk . But sometimes they later could not remember having done any of those things medical diagnosis for low testosterone . It was as if a piece of their memory had been erased, like words from a blackboard evista rod . There were also reports of depression associated with Halcion use and even some suggestions that it was linked to violent and aggressive
behavior advil versus aleve .
With all the bad press, Halcion in particular and sleeping pills in general fell into disfavor j-tube and prevacid . A lot of insomniacs worried about drug dependency, morning grogginess, and memory lapses buy aquazide esidrix online ezide hydrochlorothiazide . Instead, they chose to toss and turn rather than rely on benzodiazepines like estazolam, flurazepam, quazepam, temazepam, and triazolam order cheap viagra .
Then along came zolpidem (Amblen) in 1993 caffeine plant growth cafeine growth plant . It gradually captured the sleeping pill market cheep generic viagra . Eventually zaleplon (Sonata) showed up, but the real competition didn’t arrive until 2005 in the form Of eszopiclone (Lunesta) and ramelteon (Rozerem) how to shop for tadalafil online . Sleeping Pills were aggressively marketed directly to consumers wellbutrin xl sr . The Lunesta commercial featured a beautiful green Luna moth gently fluttering through a bedroom claritin and benadryl . But just because the ads are alluring doesn’t Mean a prescription is the best approach clomid when should we have intercourse .
An in-depth analysis indicated that for the elderly, at least some sleep medications are more likely to hurt than help zyrtec can be purchased from canada .7R The medications may help some older individuals fall asleep more quickly can boniva cause tooth pain . But the overview found that, for the most part, sleeping pills have only a modest effect zoloft at night .
The prospect of dangerous side effects is especially troubling depakote gain weight . Older people taking a sleeping pill were nearly five times more likely to become confused or forgetful as those taking an inactive placebo mg caffeine sparks .703 Dizziness that might lead to a fall and daytime drowsiness that could lead to an accident were also significantly more common singulair information . These risks should lead an older insomniac to ask lots of questions about possible problems if his physician offers a Prescription fenofibrate pictures . The, authors of the review suggested that Cognitive behavioral therapy or other nondrug treatment might be preferable for some elderly people with sleeping difficulties drug effectiveness wellbutrin and cymbalta . 704
As is so often the case, there are few head-to-head clinical trials comparing the effectiveness or safety of the newer sleep aid&705 As a result, ranking them requires a certain amount of guesswork and judgment abilify obesity . Here is our overview levaquin reaction symptoms .
** Lunesta (Eszopiclone)
Eszopliclone helps people fall asleep and stay asleep tricor 145mg directions . it probably lasts a little longer than Ambien but likely is comparable to Ambien CR lithium floride glow curve . Because the manufacturer submitted a 6- month study, Lunesta is approved for long-term use prednisone half-life .
Side effects: Unpleasant taste, headache, next-day drowsiness, dizziness, dry mouth, next-day memory impairment (anterograde amnesia), difficulty with coordination Downside: Possible memory difficulties new fda drug name acomplia . Sudden discontinuation can lead to worse insomnia during the first night or two minocycline calcium interraction . Lunesta can be very dangerous if taken in combination with alcohol or other sedatives nystagmus tremor celexa 40 mg . Avoid itraconazole (Sporanox), clarithromycin (Biaxin), and ritonavir (Norvir) cymbalta falling . Cost: Approximately $100 to $110 for 1 month (30 pills)
more than a few nights at a time, this labeling is likely to propel Lunesta to becoming the most successful sleeping pill in the United States tramadol hcl dosage . Whether it deserves this marketing edge remains to be seen info on celexa . Lunesta works in a manner similar to that of Ambien and Sonata, but it has a longer-lasting effect lamisil side effects .
One study suggested that Lunesta could be used for up to 6 months without losing its effectiveness or leading to dependence tamoxifen and lamisil . Nevertheless, the FDA classifies it as a Schedule IV controlled substance, which means “limited dependence liability ibuprofen kids .” When Lunesta is stopped, rebound insomnia is a distinct possibility flagyl and macrobid .
Rozerem (Ramelteon)
This is the first truly unique sleeping pill to come to market in years seroquel defined . It targets melatonin receptors to help people fall asleep nitrofurantoin macro . Unlike all other prescription sleeping pills, Rozerem is not classified as a “controlled substance prilosec and liver side effects .” That means there are no restrictions on the length of time it can be used and no fears about abuse or dependency caffeine at night symptoms .
On the surface, it might seem as if Rozerern represents a wonderful new solution to insomnia osmolite and warfarin . Unfortunately, we are not overly impressed with its effectiveness average cost per day risperdal . In clinical trials, it reduced the amount of time it took people to fall asleep by 8 to 16 minutes norvasc aleve . 707 That may be helpful for some, but Rozerem Rozerem I(Ramelte0qW cheapest viagra and regalis .
Ramelteon helps people fall asleep baclofen and tizanidine . It works differently from all other sleeping pills and poses no risk of dependency reglan without prescription . Take it 30 minutes before retiring and not with a high-fat
meal omeprazole drugs .
Side effects: Next-day drowsiness, dizziness, nausea, fatigue, and headache
Downside: Not safe for people with liver problems what is nifedipine used for . Avoid fluvoxamine (Luvox), fluconazole (Diflucan), and ketoconazole (Nizoral) crookd penis from levitra . Safety during pregnancy has not been determined herb zyrtec . Cost: Approximately $80 to $85 for 1 month (30 pills)
did not reduce nighttime awakenings or help people get back to sleep once they had awakened cyproheptadine anti-serotonin depression . In addition, there is one side effect that bothers us vioxx celebrex bextra . The manufacturer reports that this compound lowers testosterone levels and increases a hormone called prolactin sainsburys caffeine level . This change in hormone balance may be associated with reduced libido, infertility, and osteoporosis fluconazole infants stomachs .
Sonata (Zalepion)
Sonata is a very short-acting sleeping pill that works in a manner similar to that of Ambien and Lunesta actos lawsuits . Because its effects wear off quickly, it can be used when someone wakes up in the middle of the night and cannot get back to sleep asprin and vitamin e acne treatment . The only caution, though, is that you need at least 4 more hours of sleeping time for the effects to wear off charging cr2032 lithium . If you wake up at 5:00 a ultram withdrawal symptoms .m dangers of atenolol . amoxicillin long term use for kidneys . take a Sonata, and then expect to be able to hit the ground running at 7:00 a too much synthroid medication .m what is feldene drug ., you could be in trouble aciphex and hip fracture . If Sonata is taken at bedtime, it is less RV,6y than other sleeping pills to rwist morning hangover dr affect driving ability the next day coreg varices . The downside to this short effect is that some people may wake up early in the morning because the drug’s effect has worn off synthroid and antidepressant metabolism .
For people who wake up too early in the morning, there is another trick to try cialis dreampharmaceuticals online . Bright light exposure in the evening may help them reset their body clock so that they can sleep through the night zantac picture .” Those who cannot fall asleep until the wee hours may benefit from bright light in the morning robaxin damages .
Sonata (Zaleplon)
Zaleplon is a good choice for people who wake up in the middle of the night and cannot easily fall asleep again motrin dosa . At least 4 hours of sleep time are needed levitra duration . Do not take after a fatty (heavy) meal because the food will delay absorption citalopram and duloxetine .
Side effects: Headache, stomachache, dry mouth, constipation, back pain, and occasional next-day drowsiness Downside: Sonata’s very short effect may mean that the drug wears off during the night and results in early morning awakening viagra home made . People with liver problems should avoid Sonata aleve back and body . Cost: Approximately $100 per month
Diphenhydramine
This antihistamine, the active ingredientin Benadryl, is noto- rious for causing drowsiness japanes green tea caffeine . During the daytime, this side effect is a real liability if you want to drive or do anything that requires alertness does medicaid cover zoloft . But at bedtime, drowsiness might be a good thing prednisone horse dosage . ‘There are many over-the-counter sleeping pills that contain diphenhydramine (Nytol, Simply Sleep, Sominex, Unisom Sleepgels, etc lipitor radio control car .) zocor benefits side effects . The manufacturers of nighttime pain relievers like Alka-Seltzer PM, Exedrin PM, and Tylenol PM have been successful at getting consumers to buy into the need for a combination analgesic and sleep aid synthroid maintentance dose based on weight .
• • •
O diclofenac tabs . Several years ago I developed severe dry eyes celebrex pill photo . About a year later, my husband developed the same condition ivermectin liquid compounded . The only common denominator our doctors could find is that we were both taking Tylenol PM to sleep at night lexapro celexa .
The ingredient that helps one sleep in that product is an antihistamine, which can be drying premarin pronounced . Your readers should be told topamax warfare .
A prescription drugs lexapro . Diphenhydramine, which puts the PM in Tylenol PM and many other nighttime pain relievers, can dry out mucous membranes lariam side effects class action . Sensitive individuals could notice dry mouth benadryl with singulair . This is the first time we have heard that this antihistamine may also cause dry eyes clomid and follistim .
• • •
The main problem with diphenhydramine as a steep aid is that some people experience next-day grogginess 5 cheapest sildenafil citrate 56 . As a result, driving performance may be impaired; In addition, some peo- ple may experience dry mouth or difficulty with urination indian sildenafil without prescription . The sleep-inducing effect can wear off after a few days cytoxan metabolism speed .”O Older people may be especially vulnerable to side effects such as cognitive impairment viagra enhancements .
Conclusions
Getting a good night’s sleep is crucial for good health does medicare pay for viagra . We never cease to be amazed that health-conscious people who exercise, eat carefully, and take their vitamins often skimp on sleep lyme disease treatment with azithromycin . We hope you will make getting adequate sleep an important health priority doxycycline for rosacea . If you can find a psychologist who specializes in cognitive behavioral therapy for sleep disorders, this approach may be the safest and produce the longest-lasting benefits ultram er 300 mg .’”
Here is an overview of our other recommendations pre emptive analgesia etoricoxib .
• Practice good sleep hygiene itraconazole liver function tests . Try to go to bed at the same time each night social anxiety disorder celexa . Avoid alcohol and caffeine geodon anit-psychotic dangers . Keep the bedroom dark, and do not watch TV in the bedroom ths soma in the nervous system .
• Exercise during the day (not in the evening) and take a hot bath about an hour before bedtime zocor with chantix .
• A high-carb snack before bedtime may raise serotonin levels, helping you fall asleep levaquin tablet cost . Relax with soothing music or a relaxation CD tramadol vicodine taken together .
*Cognitive behavioral therapy is one of the most cost-effective approaches to insomnia azithromycin stomach flu . Finding a practitioner with experience will be your biggest challenge soma 78 restaurant tucson .
*Try magnesium supplements before bed rx board viagra . As long as your kidneys are healthy, 250 to 500 milligrams may help atorvastatin pravastatin simvastatin rosuvastatin lovastatin . If you develop diarrhea, reduce the dose glaucoma topamax .
• Aromatherapy may be helpful side effects of levora . The scents of jasmine or lavender can be relaxing and facilitate sleep buy cheap viagra prescription online .
• If a nondrug herbal approach appeals to you, valerian is our first choice buy online prilosec . We would recommend a standardized ex- tract of 300 to 600 milligrams before bed attack mefloquine panic . Several days to 2 weeks may be needed to see results lithium manganese battery 123a .
• If a sleeping pill is your last resort, we suggest zolpidem loperamide dose dogs . Because it is available as a generic, it will be the most cost-
effective citalopram side afects .

Care
Boundaries
Birth is an immense change for the baby. Her whole physiology changes fundamentally and she experiences a completely new environment. The boundaries of the womb are left behind and she enters a ‘boundless’ world. In the womb, the child was able to grow harmoniously, protected from the world.
This reveals that everything that is developing requires a protective environment. With a newborn baby, and actually throughout childhood, this protective environment is constantly provided to establish firm foundations for later life. Unconsciously, the child is constantly reminded of the situation in the womb, which is related to an experience of security, safety, protection and fundamental confidence.
Warmth
The womb not only protects the embryo from the world; it also surrounds it with an even temperature of 37°C (98.6°F). A ‘warm environment’ is provided in the best possible way.
After birth, a child has to learn to maintain her own body temperature at a constant level, at first with the help of adults. She must interrelate the warm and cold parts of the body. This is achieved by means of a sensitive metabolic process which generates heat.
Normal growth and the development of the normal physical processes are also dependent on this metabolism. All the heat which the baby does not have to produce herself in order to maintain her temperature at the right level will benefit growth.
It takes the child a long time to regulate her own temperature; the normal difference of PC (2°F). between the body temperature during the night and the day is achieved by most children between their fifth and ninth months. Up to that time they are extremely dependent on the extra warmth provided in the form of good physical care, clothes, and hot water bottles used to warm the cradle before they are placed in it.
The ability to distinguish whether something is hot or cold is learnt during the initial period. The better this ability has been developed by providing sufficient warmth in childhood, the better the child can use it at a later age.
Cold feet are an important sign that extra attention should be devoted to regulating the child’s temperature. A baby should have warm feet, warm legs, a warm body and warm arms.
Special attention to warmth also has another significance. A warm environment helps the child to ‘warm up’ for life on earth. However, our motto is not ‘the warmer, the better,’ because always being dressed in too many clothes or being covered up can actually make a child either drowsy or very restless, and overheating can be very dangerous. Detailed research has revealed that there is a relationship between overheating and cot death. Duvets and synthetic materials can especially cause overheating. Therefore we certainly advise against using these.
In our view, the important thing is to learn to observe the needs of the child with regard to warmth, and to read the signs when more or less warmth needs to be provided in the form of clothes, bedding or ambient heating. The body temperature of the child is the most important thermometer, and in a healthy baby, this fluctuates around 37°C (98.6°F). You can learn to take the baby’s temperature with your hands so that you can literally feel how the child is regulating its own temperature. In the first week or two after birth, take the baby’s temperature every day, as well as feeling how warm she is. Then start testing yourself: feel how warm the baby is, then predict her temperature and check with the thermometer for a few days. If your predictions are correct, you will only have to take the baby’s temperature when you are doubtful or if she is sick.
Impressions
Everything we do, feel and think around the child is assimilated by the child. She is still completely open and has a boundless trust in the environment. The buffer which
we have between ourselves and the world as adults is formed by recognising and understanding that world. A small child is not yet able to do this. Up to about the third year, the child identifies with the environment in which she is living in a very natural way. This is followed by a stage in which thinking gradually assumes set patterns, and the child leans to distinguish herself from the outside world. For the first time, she makes a distinction between her own individuality and the world which is perceived. In this light it is understandable that first memories only go back to the third year, and there are no, or very few, memories before this.
The child is one big sensory organ. Up to the third year, all impressions are assimilated in an uninhibited way and disappear into the subconscious. There they are combined with other physical processes, and a sort of print is made; it is as though the child models the influences of the environment in its own `clay.’ Therefore, it is important that we are aware of what ‘goes into’ the child — also for later on.
Example. A child in a boat on the water, experiences the swell, feels the sunlight on her skin and the wind in her hair, smells the odour of water and fish, is taking in healthy impressions which build up the whole organism. The situation is quite different for a child at a department store who is placed in a rotating ship, which goes round and round when a coin is placed in the machine. The child will enjoy both these experiences, but they affect the organism in significantly different ways. The ‘boat on the water’ situation sounds idyllic; this is usually a vacation experience. However, there are also impressions closer to home, which can be constructive and have the above-mentioned character
Positive, constructive impressions are those impressions in which the natural origin of materials, sounds etc, can be perceived by the child. For hearing, these are the sounds of people and animals, and natural sounds such as the rustling of the wind. For sight, they are natural colours. For the sense of touch, they are materials such as wool, cotton, silk, wood, sand and water.
Many domestic appliances such as vacuum cleaners, washing machines, radio, television and plastic toys were created as a result of human technical ingenuity. For children, these are actually an abstraction, lacking in natural connection.
Radio, television and plastic toys are things you can consciously choose to have or not to have in a small child’s immediate environment. With household appliances, you can take care to minimize the sound in the baby’s immediate environment. So-called ‘white noise’
from household appliances is not a good idea for the young child as it blocks out normal impressions. Autistic children can also become obsessed by white noise. Playing a lyre, humming or singing are better background sounds for the child.
Simple actions such as washing hands, or sweeping up with a dustpan and brush in the child’s presence show how things are done. These actions are enjoyable and you can invite children to imitate them.
The feelings of people around the child also have an effect. It is obvious that a child will thrive best in a genuine atmosphere of joy and warmth. This has a positive effect. But there is not a parent in the world that is always cheerful and relaxed at every moment of the day (and night). It is worth aiming to achieve these qualities, but at times when you do not succeed, you must take them for what they are — also real human emotions. In every family there are days when everything goes pear-shaped and the ideal image of a happy family seems a long way off. Humour is always a good remedy. It can be a relief if you can laugh about yourself and the situation.
The needs which were mentioned above — that is, the need for boundaries, warmth and positive impressions — make great demands on the environment. It means that parents must have clear insight and a good level of empathy to get things right: too cold or too warm, too many im-pressions or too quiet, well-protected or not enough room to breathe?
From this point of view, we would like to discuss a number of practical aspects of childcare.
Clothes
Clothes are like a second skin, which support the functions of the skin. The skin helps to regulate body temperature and protects us from infections. In addition, the skin is a sensory organ with which we perceive the environment. These three functions are most effectively supported with clothes made of wool, silk, cotton or hemp. These fibres are preferable as they provide sense impressions from a natural source via the skin, which help the child to build up its body. Other fibres are more alien, and even viscose, which is made from cotton or wood, is processed quite strongly, in a way which is now known to be quite polluting.
Wool
Sheep’s wool protects the sheep from heat and cold, rain and toxic waste. The curls trap the warm air around the sheep’s skin. The wool keeps out the rain, and waste products are absorbed and emitted through the wool via perspiration.
All these qualities are found in woollen clothes. The warmth of the wool protects the child from cooling down too quickly and supports her unstable heat regulation system which cannot yet retain body heat.
Its absorbent capacity (30 to 40%) ensures that the child remains comfortably dry. The quality of the wool depends on the age of the sheep, the animal’s diet and health, as well as the way in which the wool was turned into clothing.
Finely knitted woollen vests are available, which forma soft, flexible outer skin. Woollen jumpers and cardigans should be loose fitting so that they are easy to put on and take off. Woollen pants are wonderful to use over cotton nappies. They can be knitted easily, preferably from slightly greasy sheep’s wool, and are ideal for absorbing moisture and neutralizing the waste products in urine.
A woollen shawl will keep the baby warm when there are fluctuations in temperature. Woollen socks will also keep the feet nice and warm. Furthermore, wool does not attract dirt, and therefore woollen clothes do not have to washed as often as cotton clothes, though they do have to be aired regularly.
Silk
The silkworm spins its cocoon of silk thread, in which the worm is sealed off from any negative external influences. The silk is made under the influence of sunlight — at sunset, the silkworm stops spinning, and at sunrise, it starts work again.
If you use silk in clothes, you will feel its enclosing qualities. Furthermore, silk can absorb 30% of its weight in moisture without feeling damp. In addition, silk retains heat when it is cold and releases heat when it is warm. That is why silk is worn especially in summer. Silk and, in particular, knitted silk is an excellent basic material for vests, but it is advisable to put a woollen vest over the silk vest as well.
Children who are sensitive to wool against the skin, and children who are very sensitive to impressions and consequently become restless, will benefit from wearing a silk vest.
Cotton
Cotton is widely used nowadays for children’s clothes, especially as this material can be washed so easily in the washing machine. At the same time, it should be said that it actually has to be washed often because it attracts dirt easily. Cotton can absorb 20% of its own weight in moisture.
As cotton cannot absorb heat, this passes easily through the material to the outside air. Consequently, this material is not the best choice for a child’s underclothes throughout the year. Furthermore, the way in which cotton is grown is not particularly environmentally friendly, and chemical products are often used in the treatment of the material. Fortunately, there are several eco-cotton projects which now promote its environmentally-friendly cultivation and processing, and eco-cotton is becoming increasingly available in shops and over the internet.
We suggest dressing the baby in at least two layers of clothing, covering the whole body, including the arms, legs and feet. This produces a layer of air between the two layers which retains heat. In a temperate climate, a long-sleeved woollen vest — or a vest of wool and silk — can be worn for most of the year.
In practice, we regularly find that babies are not dressed warmly enough, and they are often restless and troubled by stomach cramps, or they are constantly crying. The simple remedy of dressing the child more warmly, in better fitting clothes, will do wonders for this.
Bonnets
Unfortunately, bonnets are no longer in fashion. In comparison with the rest of their bodies, little babies often have an enormous — and sometimes rather bald — head. The head is constantly losing heat, which should really be retained for the development of the brain and organs. On the one hand, a silk bonnet will retain the baby’s heat, and oil the other hand, it protects the head and the open fontanel from a restless environment. It is important for the forehead to be free, because this part of the body acts as a sort of thermostat for regulating body heat. Where it is often windy, it may also be necessary for the baby to wear a second bonnet made of wool. There are wonderful bonnets on sale, or they can be knitted in material which is so soft that it is like a second skin.

Bonnets can be removed when the child is in the cot as long as the baby is well protected.
Wraps and swaddling
Because of the need for boundaries, it is understandable why many babies, as well as older children, calm down and fall asleep easily when they are firmly tucked in, or if they are wrapped up or swaddled.
Usually, babies have a flannel sheet wrapped around them, during the postnatal period, but this often disappears, to be replaced by a babygro/sleepsuit. We recommend continning to use a swaddling cloth and wrapping it firmly around the babygro/sleepsuit before putting the baby to bed (see illustration). As the baby still lies with its arms and legs bent, it should be swaddled in this position, to increase the sense of security. The baby can now relax and will fall asleep warm and snug. However, you must make sure that the baby is not wrapped up too warmly (see p.25).
The woollen wrap can serve as a blanket outside the cot for when the baby is fed. When the woollen cloth is no longer sufficient, use a (woollen) baby sleeping bag for in bed.

Children who remain restless and have difficulty falling asleep despite being wrapped up, as well as babies who do not establish a good rhythm of drinking/sleeping, may benefit from the old-fashioned method of swaddling in which the arms are also wrapped up so that the child cannot flail about. Flailing is often a response to crying, cramps or fright, but because it is involuntary, it can cause new restlessness. Swaddling can help to break this vicious circle.
Many parents find it difficult to restrict their baby in this way; in our age of boundless freedom, it is not so easily accepted. However, parents usually overcome their resistance when they see how the baby responds to swaddling. For most babies, it results in a much greater sense of peace, and consequently they sleep well and establish a pattern of sleeping and feeding every few hours. Nowadays, two methods of swaddling are recommended: either ready-made swaddling blankets or swaddling wraps, or using the method shown at the back of this book (see p.108). (See also Blom, Crying and Restlessness in Babies.)
The cradle
The cradle is an important successor of the smallest home in which the baby lived before birth. You can opt for a basket cradle (Moses basket), a wooden (rocking) cradle or
a cot. For safety considerations, the baby’s feet should always be placed at the end of a cot, with its head halfway down. Tuck in the blanket in such a way that the head is free and the shoulders are covered. A hood or canopy over the cradle or cot makes the space more intimate, so that the child is not distracted by the environment and can sleep more peacefully.
For the canopy, it is best to use plain materials in soft colours. A canopy made of light blue silk combined with a layer of pink silk gives a very subtle calming colour.
The mattress must be absolutely flat, providing good support, and it must be well-ventilated and warm. Our preference is for a mattress of kapok, cotton or another natural material. A sheep’s fleece can be placed on the mattress. The fleece is soft and gives a beneficial warmth so that the newborn baby is protected from cooling down too quickly. Make sure that the fleece is not too large and lies on the mattress without any folds. Cover the fleece with a sheet. The bedding should be made of cotton and wool. Do not use synthetic materials. The sheets and blankets should be big enough to tuck the baby in quite firmly. The fleece and the mattress should be regularly aired. If you use a woollen wrap there are likely to be patches of damp under the mattress. If necessary, use a waterproof sheet. There are cotton sheets available that are impregnated with rubber and do not feel clammy. We do not recommend the use of duvets, even those made of wool, because of the risk of suffocation.
If the cradle is next to the window, watch out for overheating in the sun. A baby can easily become too hot in a heated room when the sun shines through the window.
The playpen
Up to the age of four months, it is not really necessary to have a playpen. Nevertheless, when the baby is downstairs, it is a good idea to have a safe place to place it. A wicker basket with a soft cover, or the bed of a pram, are quite suitable.
We do not recommend the frequent use of a baby seat or recliner, as the baby is stimulated by the ac-
tion of sitting in an upright position at a stage when he is still physically immature. The baby can only lie passively in a baby seat, which does not matter for a short period, but is harmful to physical development in the long term.
This objection does not apply so much to the use of a recliner, but there are other objections; when the baby discovers that he can bounce the recliner with one leg, he often finds it difficult to stop, even when he gets tired of the mechanical movement.
When the baby starts to reach out for things and becomes more active in its motor development, it is time for a playpen. Quite apart from the fact that this provides a safe place for the child to learn to sit and stand, it is often a favourite place for being quiet and for playing undisturbed. A cloth cover, like a curtain, along three sides of the playpen will increase the sense of security, and is not to be confused with cot bumpers, which are not recommended as they pose a suffocation risk for the young child. For motor development, it is important that the floor of the playpen is sturdy and not too smooth (for example, a cloth folded double), so that the child can roll over and can put pressure on it.
Walkers and baby bouncers
We emphatically advise against the use of walkers and baby bouncers. These are ‘aids’ which speed up the child’s motor development in an unnatural way. Children certainly like to use these things — especially if they can move around in them quickly — and want to use them more and more. However, it is much better for a child to learn to stand and walk at his own pace. In this sense, walkers and baby bouncers do not help healthy development in any way, and are actually more of a deterrent to healthy development.
Prams and baby carriers (slings)
The pram can be a safe and sheltered place in which the baby can sleep outside during the first few months. For walking, a baby carrier is often a better alternative because it means
that the baby moves in time with the pace at which the adult is walking, and is not shaken about so much as in a pram, as it goes up and down the pavement. The child is carried in a natural position in a baby carrier (sling), (see the illustration on p. 106).
However, at this point a warning should be given. It has been shown that babies can become too hot and stuffy, particularly if carried under a coat. Unfortunately, there are even a few cases, which resulted in a baby’s death. We recommend that you keep a careful eye on a baby in a baby carrier, and if possible carry it on top of a coat rather than underneath, with, if necessary, a woollen cloth around the baby.
The disadvantage of a baby carrier in which the baby is in a vertical position is that the baby did not take up this position itself. In this sense, the baby carrier is not for babies until they reach the age of nine months. A sling is preferable, as the whole back and head are supported, although it might be tiring for the mother to carry.
When a baby has reached the age for a pram, the best model is one in which the baby faces the parent. In this way, the baby constantly has the comforting face of its father or mother in front of it, and can find out from that face what is happening in the big wide world. A traditional pram has the advantage that the child lies flat, as at this age the baby’s head is still relatively heavy and the neck cannot keep the head in a stable position. We recommend a buggy only from the age when the child is able to sit unassisted.

Not Getting Pregnant FAQs.

We’re not getting pregnant what do we do now?
We’ve been trying to conceive for 12 months - can the doctor identify the problem?
There are many factors that can increase or decrease your chances of becoming pregnant, but if you have been trying for a year, it would be sensible to contact your doctor. After an initial assessment of your general health and lifestyle, your doctor will offer your partner a sperm test (see below) and you will be offered tests to see if you are producing eggs and check whether or not your Fallopian tubes are blocked. Blood tests will be carried out to check your iron levels, your red and white blood cell count, and to check how organs such as your liver and kidneys are functioning In addition, couples are asked to agree to a sexual health screening to check for previous or current STls, such as HIV and syphilis.

My wife has been tested and has the all clear - how can I tell if I’m causing our fertility problem?
You will be offered a semen analysis to determine your sperm quantity and quality — how sperm move (motility) and whether they are a normal form. A healthy sperm count should have a concentration of 20 million spermatozoa per millilitre of semen, with
75 per cent of these alive and 50 per cent of these ‘motile”, or moving as well as possible Differences can occur over time in both the quality and quantity of sperm, so if your first sample is poor, you will probably be tested again a couple of months later.
You are also likely to be advised to give up smoking, reduce alcohol intake to 1-2 units once or twice a week, and to wear loose-fitting underwear to avoid overheating the testes If a problem is found, you will be referred to a specialist for a consultation Try to avoid becoming stressed as this can also affect fertility Learning relaxation techniques with your partner and practising these regularly will help.

We can’t conceive naturally - what do we do now?
Assisted conception; or assisted reproduction, is the term used when women are helped to conceive without having intercourse There are five main procedures available, listed below. Your consultant will go through each one with you, and together you can make a decision about which is most suitable depending on your problem. You can also contact the National Institute for Health and Clinical Excellence (NICE) for more information (see p.310)
* Ovarian Stimulation (OS), or Super Ovulation (SO), involves injections of fertility hormones to boost egg production This is followed by intrauterine insemination (IUI) of sperm, whereby sperm are collected and sorted so that only the strongest remain and these are then artifically placed inside the uterus via a catheter. This is ideal for couples when the man’s sperm is “slow” or the woman has problems ovulating, or there is a combination of both. * Gamete Intra-Fallopian Transfer (GIFT). This is suitable for couples for whom no cause for infertility has been found. It involves stimulating the ovaries to produce eggs, which are removed, mixed withsperm and replaced directly into the Fallopian tubes, allowing conception to occur inside the body.
* In Vitro Fertilization (IVF). This is the most widely used treatment and involves a seven-step process (see below and p.30) This is ideal for most problems including blocked tubes
* Intra-Cytoplasmic Sperm Injection (ICSI). This is used if the man’s sperm count is low, the motility of the sperm is very poor, or the woman is allergic to her partner’s sperm. The treatment involves injecting just one viable sperm into an egg (see box right). * Artificial Insemination by Donor (AID). This is simply the injection of donated sperm into the cervix This is used when a man is unable to maintain an erection or is sterile Similarly, women may require an egg donation if they are unable to produce their own eggs, although this is more complicated.
Whatever treatment is provided, it is important that you and your partner are treated as a couple rather than separate patients. It is also essential that you are kept informed throughout the process and given information on any risks and benefits.

What does IVF involve?
IVF, or In Vitro Fertilization, involves the surgical removal of an egg which is then mixed with sperm in a laboratory dish to fertilize and produce an embryo outside of the womb (see p.30).
IVF treatment occurs in cycles, as there are various stages that must be completed for it to be successful. Initially, a drug is used in the form of a nasal spray or injection to switch off the woman’s natural cycle of egg production in the ovaries, known as ”clown-regulation”. Fertility drugs are then given to stimulate the ovaries to produce more than one egg (ovulation induction). Mature eggs are collected from the ovaries using a fine needle guided by ultrasound. The procedure is usually uncomfortable rather than painful. On the same day, the partner’s sperm is collected and then the eggs and sperm are mixed in a dish. Within a few days, one or sometimes two embryos are transferred into the womb. If an embryo successfully attaches to the inside of the womb and continues to grow, a pregnancy results.

ICSI

This procedure may be used when it is thought that the quality of the partner’s sperm may be responsible for fertility problems. If the sperm count is low or movement is poor, sperm may be ”assisted” in fertilizing the egg. An individual sperm is injected directly into the egg and, if fertilization takes place, the resulting embryo is placed in the uterus.
What are the success rates of fertility treatments?
Success rates for treatments vary, depending on the treatments used and the health of the couple If you want to know the success rates of individual clinics, you can ask for their ratio of “live-births-per-cyclestarted”. This information is available from each clinic, but there are currently no nationally held data
Overall, couples have a better success rate if the woman is aged 23-39 years, has been pregnant or has had a baby, and has a normal body weight (a body mass index between 19 and 24). The older a woman is, the less likely she is to get pregnant
Figures show that for every 100 women who are 23 to 35 years, more than 20 will get pregnant after one PVT cycle; from 36 to 38 years around 15 will get pregnant at 39, around 10 will get pregnant; and in women over 40, around 6 will get pregnant

IVF is so expensive - can we get help with funding?
Since April 2005, women between the ages of 23 and 39 are entitled to one free IVF cycle on the NHS. However, you must meet the eligibility criteria set by your local Primary Care Trust (PCT), which varies across the country and depends on factors such as your marital status, weight, and whether you or your partner smoke Couples who can afford to, or who may have had one unsuccessful cycle already, often opt for a private clinic Although these are regulated by the Human Fertilisation and Embryology Authority (HFEA), this cannot set costs, and a private course of IVF can cost from E4,000 to £10,000
My partner is worried about producing his sperm sample. How can I reassure him?
As fertility problems affect 1 in 7 couples in the UK reassuring your partner that this is not an unusual situation is always a good start. You could try leaving out a leaflet on fertility problems for him to read for more information Try to empathize with him as much as possible by sharing your experiences and the tests you have undergone.
Your partner may be worried about ejaculating at the required time when he is already feeling anxious and is in a clinical environment Some men require a sex toy, magazines, or video clips to help. For others, restraining from sexual intercourse for a few days can make ejaculation easier If you live fairly close to the clinic, your partner may be able to produce the sample at home and deliver it.
Sometimes a medical condition such as diabetes prevents a man ejaculating If this is the case, sperm can be obtained through ‘’sperm recovery”, whereby a small needle is passed through the skin of the scrotum into the testes and sperm is withdrawn.

The drugs I’m taking for IVF are giving me terrible mood swings. Is this normal?
The drugs used in IVF treatment are female hormones (see p.30) to stimulate your ovaries to mature more than one egg at a time, and progesterone, which helps to sustain a pregnancy. Different levels of hormones can result in mood swings, as any woman who suffers with premenstrual tension (PMT) can testify, and this is also a common side effect of IVF treatment It’s worth considering too that couples undergoing IVF are under incredible stress, which has been linked to an increased risk of developing depression, so it’s important to decide whether you are feeling ”hormonal” or are in fact depressed. Your doctor can advise you and refer you if necessary.
My partner has a low sperm count - can you tell us what help is available for us?
Usually, two or three semen samples are taken to work out the average sperm count and to see if there are abnormal sperm present. A healthy semen sample of 2-5ml contains more than 20 million sperm per ml; a count below this is considered low If your partner has abnormal sperm, further testing may be necessary Lifestyle changes can boost sperm (see below). There are also hormonal treatments to improve sperm count and surgery to remove blockages You may be reassured to know that even poor-quality semen can be used to fertilize an egg with IVF or with ICSI (see p.29).
Can lifestyle changes really improve sperm?
Poor quality sperm has been linked to excessive drinking (more than three or four units of alcohol per day), smoking, and to wearing tight-fitting underwear,
which overheats the testicles and can affect their efficiency Excessive stress and a poor diet are also thought to affect sperm So yes, it is worth reviewing your lifestyle to see if improvements can be made Jobs that may expose you to harmful agents, such as pesticides, may also affect sperm, so if you think your partner’s job may pose a risk, it’s worth investigating.
I’m pregnant using a donor -what happens if my child wants to trace her biological dad?
From April 2005, children who were conceived using donor sperm have had a right when they reach 18 years of age to find out their parent’s identity. This also applies to children conceived using donor eggs and embryos. This right applies only to children conceived after this date and not retrospectively. Prior to this date, children had the right to know at 18 years of age if they were conceived using donor sperm, eggs, or embryos and to find out if they were related to someone they wanted to marry. The reason for this change in the law is that children conceived in this way are being given the same rights as adopted children regarding information on their genetic parents. However, some fertility experts fear that this will deter potential donors.
Is surrogacy allowed in the UK?
Currently, surrogacy is legal in the UK, although it is illegal to advertise it as a service However, the law does not recognize surrogacy
as a fixed agreement, which means that a surrogate can change her mind about the arrangement during the pregnancy and up to six weeks after the birth. It is usual for a surrogate to receive ”reasonable expenses”, although there is no definition of what is deemed as reasonable. Usually, this includes costs incurred by the surrogate relating to her pregnancy, If the father of the child is named on the birth certificate, this gives him equal rights to the child. If this is not the case, then six weeks after the birth the new parents can apply for a parental order that gives them full parental status At this point, the surrogate gives up any parental rights to the child.

Conception problems

There are a range of reasons why a couple may have difficulty in conceiving. Investigations and tests may uncover specific conditions, which may be treatable, or you may be offered help to conceive.
What can affect a man’s fertility? A semen analysis may reveal various reasons why sperm have difficulty in fertilizing an egg The sperm count may be low (less than 20 million sperm per ml); the motility of the sperm (how they move) may be poor, and there may be a high percentage of abnormally formed sperm Some men experience a failure to ejaculate at orgasm There may also be damage to the tubes that connect the testicles to the seminal vesicles where sperm are produced, and this may have been present from birth or caused by a later infection
What can affect a woman’s fertility? Conditions such as polycystic ovary syndrome
(a hormonal imbalance that causes ovarian cysts) and endometriosis (see p 19) can disrupt fertility. Other hormonal imbalances, such as low levels of FSH and LH, can affect ovulation; or levels of progesterone may be too low to sustain a fertilized egg. Damaged Fallopian tubes, caused by an ectopic pregnancy (see p 25), surgery endometriosis, or pelvic inflammatory disease, which may be caused by an infection such as chlamydia, can prevent conception. Damage to the ovaries can occur from scarring as a result of surgery or infection, or the supply of eggs may be low Some women have an abnormally shaped uterus, or have uterine scarring, that can prevent the successful implantation of an egg.

IVF treatment

In vitro fertilization or IVF, is a complex procedure with several stages, from the stimulation and harvesting of your eggs to the successful fertilization of the eggs, development of embryos and transfer of the embryos into the womb for implantation. Undergoing IVF can be a stressful and time-consuming undertaking, but knowing in advance how the procedure works and what you can expect at each stage can reduce anxiety and help you and your partner to cope.
What happens first? To optimize the chances of success with IVF more than one egg at a time is removed for fertilization Normally, your body produces one egg each month. In rVF, you will inject yourself with drugs, such as clomiphene and hMG (human menopausal gonadotrophin) to stimulate your ovaries to produce several eggs. While you are undergoing this treatment, you will need to visit your clinic every one to two days over one or two weeks to monitor the development of the eggs. Once it is thought that the eggs are mature, you will be given a blood test to measure your levels of oestrogen, which is released around ovulation.

What happens next? Once your follicles are ripe and ready for ovulation, your eggs will be collected at the clinic using ultrasound or laparoscopy to guide a probe. Once the eggs have been collected, they will be mixed with your partner’s sperm in a Petri dish in a laboratory ready for fertilization Your partner needs to produce the sperm on the same day as the egg collection. He can either do this at home, or come into the clinic with you and produce the sperm while you are undergoing the egg collection procedure.What happens in the laboratory? Once the egg and the sperm have been mixed, they are placed in the laboratory and monitored closely for the next few days. They will first be inspected around 18 hours later to see how many of the eggs have been fertilized and the clinic will usually pass this information on to you the day after the procedure It’s quite common for not all of the eggs to be fertilized and for only two or three to develop into embryos. The fertilized eggs are incubated in the laboratory over the next couple of days and their progress measured. The laboratory technician watches cell division under a microscope, waiting for the eggs to divide into two or more cells on their journey to becoming a blastocyst (see p.21).
If one or more fertilized eggs develop in the laboratory, you will be called back in for the embryo transfer, This is done by injecting eggs through a catheter into the uterus. No more than two eggs will be transferred and you will have the option to freeze any remaining embryos.

Surrogacy
A surrogate mother is a woman who reaches an agreement to carry a baby on behalf of another woman. She can either conceive the baby with the partner’s sperm, in which case she is the maternal mother, or the infertile couple may fertilize their own egg through fertility treatment, which is then transferred into the uterus of the surrogate mother for her to carry the baby through pregnancy and deliver at birth. This process can be beset with problems: such as the conflicting emotions of both the surrogate mother and the receiving couple, or legal issues if, for example, the surrogate mother has a change of heart after the birth and wishes to keep the baby, For this reason, it is important that all parties entering into the agreement have carefully considered the implications and are confident and happy in their roles.